AptBacterialDB

Browse by Aptamer Modification

This page provides a statistical overview of antibacterial aptamer entries categorized according to the chemical or structural modifications introduced in the aptamer sequences. For more information refer to the User Guide.

Modification Statistics (Total Entries: 2131)
Modification (190) Count
N/A 444
5'-FAM Labeled 409
5'-Biotinylated 169
5'-Amidation (NH₂) 55
5'-Biotinylated and 5'-FAM Labeled 53
5'-FITC Labeled 48
5'-Thiolated (HS-(CH2)6) 41
DIG (Digoxigenin) Labeled 40
5'-Amidation (NH₂-(CH2)6) 39
5'-Thiolated 36
2NapdU and 5′PBDC (photocleavable biotin, D spacer, Cyanine3 (Cy3) Labeled) and 3’-Inverted Thymidine (3'-idT) 35
3'-FAM Labeled 30
5'-FITC and 5'-Cyanine5 (Cy5) Labeled 29
5'-Biotinylated and 5'-FITC Labeled 29
Biotinylated 28
AlexaFluor 488 Labeled 24
FITC Labeled 22
Biotinylated or FITC or TAMRA Labeled 21
TrpdU and 5′PBDC (photocleavable biotin, D spacer, Cyanine3 (Cy3) Labeled) and 3’-Inverted Thymidine (3'-idT) 21
5′-DIG (Digoxigenin) and 5'-FAM Labeled 20
FAM Labeled 20
2'-Fluoro pyrimidines (2'-F-RNA) 18
5'-Thiolated and 5'-FITC Labeled 18
5'-Radiolabelled (32P-labeled) 17
5'-Radiolabelled ([γ-32P]-ATP-labeled) 16
NapdU and 5′PBDC (photocleavable biotin, D spacer, Cyanine3 (Cy3) Labeled) and 3’-Inverted Thymidine (3'-idT) 15
5' or 3'-FAM Labeled 14
5'-Amidation (NH₂) and 5'-Biotinylated 12
5'-Fluorescein Labeled and 3'-Biotinylated 12
Phenol-modified dUTP (dU^yTP) 11
3'-Amidation (NH₂-(CH2)6) 10
PPdU and 5′PBDC (photocleavable biotin, D spacer, Cyanine3 (Cy3) Labeled) and 3’-Inverted Thymidine (3'-idT) 10
5'-Biotinylated (biotin-C6) 9
5'-Cyanine5 (Cy5) Labeled 9
L-DNA Spiegelmer 8
2'-Fluoro pyrimidines (2'-F-RNA) and AlexaFluor 488 Labeled 8
TrpdU (5-tryptaminocarbonyl-dU) and 5′biotin-dA or 5′fluorescein-biotin-dA and 3’-Inverted Thymidine (3'-idT) 8
NapdU (5-naphthylmethyl-aminocarbonyl-dU) and 5′biotin-dA or 5′fluorescein-biotin-dA and 3’-Inverted Thymidine (3'-idT) 8
3'-Biotinylated 7
2'-O-methyl and 2'-Fluoro pyrimidines (2′-F-dGTP and 2′-OMe-dATP/dCTP/dUTP); 5'-Amidation (NH₂) 7
5'-COOH (Carboxylated) 7
5'-FAM Labeled and 5'-Amidation (NH₂) 7
Biotinylated or FAM Labeled 6
3'-Thiolated (SH-(CH2)3) 6
3'-Amidation (NH₂) 6
3'-Thiolated (HS-(CH2)6) 6
5'-DTPA dithiol and T at 86 position is replaced by 5-Octadiynyl dU moeity 6
5'-Thiolated and 5'-FAM Labeled 6
5-(2-naphthylmethyl)aminocarbonyl (2NapdU) and 5′photocleavable biotin, a D-spacer and Cyanine3 (Cy3) Labeled; 3’-Inverted Thymidine (3'-idT) 6
5'-DIG (Digoxigenin) Labeled 5
3'-Fluorescein Labeled 5
5'-and 3'-Biotinylated 5
3'-Cyanine3 (Cy3) Labeled 5
3'-Thiolated 5
5'-Amidation (NH₂) and FITC Labeled 4
5'-Biotinylated or FITC Labeled or Thiolated 4
5'-Cyanine3 (Cy3) Labeled 4
5'-Biotinylated (Biotin-(CH2)6) 4
5ʹ-Phosphorylation or 5'-FITC Labeled 4
5'-PolyA (10A) and Five thymine (5T) 4
5'-PolyA (30A) and Five thymine (5T) 4
5'-DIG (Digoxigenin) Labeled and 5-tryptaminocarbonyl-dU (TrpdU)) 4
2'-Fluoro pyrimidines (2'-F-RNA) and Radiolabelled ([α-33P]-GTP labeled) 3
5'-Biotinylated and AlexaFluor 647 Labeled 3
2'-Fluoro pyrimidines (2'-F-RNA) and A(16) extended on the 3' 3
5'-Fluorescein Labeled 3
5'-FAM Labeled and 3'-Amidation (NH₂) 3
5'-FAM Labeled, 3'-Thiolated and Poly-D-Lysine (PDL) 3
5'-Amidation (NH₂-(CH2)6) and 5'-Radiolabelled (32P-labeled) 3
2'-Fluoro pyrimidines (2'-F-RNA) or 3'-Biotinylated 3
Amidation (NH₂) 3
5'-Biotinylated and Cyanine3 (Cy3) Labeled 3
W = indole‐dU,Y = phenol‐dU,X = amine‐dU, five additional Ts at the 5'‐end, and 3'-CCATG 3
5'-Cyanine3 (Cy3) Labeled or 5'-Biotinylated and 5′ end by six nucleotides (ACT GTC), rX = RNA nucleotide 3
5′-HO(CH2)6SS(CH2)6(T)5 group, or 5'-TexasRed Labeled 3
5-tyrosylaminocarbonyl-dU (TyrdU) and 5′photocleavable biotin, a D-spacer and Cyanine3 (Cy3) Labeled; 3’-Inverted Thymidine (3'-idT) 3
5-phenylethyl-1-aminocarbonyl (PEdU) and 5′photocleavable biotin, a D-spacer and Cyanine3 (Cy3) Labeled; 3’-Inverted Thymidine (3'-idT) 3
BndU (5-benzylaminocarbonyl-dU) and 5′biotin-dA or 5′fluorescein-biotin-dA and 3’-Inverted Thymidine (3'-idT) 3
BndU and 5′PBDC (photocleavable biotin, D spacer, Cyanine3 (Cy3) Labeled) and 3’-Inverted Thymidine (3'-idT) 3
5'-Phosphate 3
3'-Amidation (CH2)5-NH₂ 2
5'-TYE 665 dye and 3'-Iowa Black end labels 2
3'-C3-Pyr 2
2'-Fluoro pyrimidines (2'-F-RNA) and 5'-Biotinylated 2
5'-FAM Labeled and Biotinylated 2
5'-Amidation (NH₂-(CH2)6) and 5'-FITC Labeled 2
Cyanine5 (Cy5) Labeled 2
5'-Amidation (NH₂-(CH2)6) and 5'-Biotinylated 2
3'-Amidation (NH₂) and 5'-FITC Labeled 2
ATTO647N-labeled 2
5'-Cyanine5 (Cy5) Labeled or 5′-Biotinylated 2
2'-Fluoro pyrimidines (2'-F-RNA) and 5'-Radiolabelled ([γ-32P]-ATP-labeled) 2
5'-Biotinylated and 3'-FAM Labeled 2
5'-Amidation (NH₂) and 3'-Cyanine3 (Cy3) Labeled 2
Y = phenol‐dU, five additional Ts at the 5'‐end, and 3'-CCATG 2
5'-Phosphate and 3'-FAM Labeled 2
FAM Labeled and Thiolated 2
5'-Amidation (NH₂) or 5'-Thiolated 2
5'-Thiolated (HS-(CH2)6), 5'-FAM Labeled and 3'-Cyanine5 (Cy5) Labeled 2
5'-Thiolated (for apt1 & apt2) and 5'-Amidation (NH₂) (for apt3 & apt4) 2
5'-Biotinylated (for ECL) or 5'-Amidation (NH₂-(CH2)6) (for colorimetric assays) 2
5-naphthylmethylaminocarbonyl-dU (NapdU) and 5′photocleavable biotin, a D-spacer and Cyanine3 (Cy3) Labeled; 3’-Inverted Thymidine (3'-idT) 2
5-tryptaminocarbonyl-dU (TrpdU) and 5′photocleavable biotin, a D-spacer and Cyanine3 (Cy3) Labeled; 3’-Inverted Thymidine (3'-idT) 2
PEdU and 5′PBDC (photocleavable biotin, D spacer, Cyanine3 (Cy3) Labeled) and 3’-Inverted Thymidine (3'-idT) 2
3'-Biotinylated (Biotin-d(A)11) or 3'-TexasRed Labeled 1
5'-Biotinylated and 3'-Fluorescein Labeled 1
AlexaFluor 647 Labeled or Biotinylated 1
5'-Fluoro-labeled with Fluorescein-maleimide 1
5'-6-hydroxyhexyl disulfide group (5'-/5ThioMC6) 1
5'-Biotinylated and 3′-DIG (Digoxigenin) Labeled 1
5′-Polyethylene glycol (PEG) with 5'-Amidation (NH₂) and 3’-Inverted Thymidine (3'-idT) and 5'-Biotinylated or 5'-FITC Labeled 1
5'-AlexaFluor 488 Labeled and 3'-(PEG)-AGGGCGC-BH1 1
5'-Amidation (NH₂-(CH2)6) or 5'-FAM Labeled 1
5' or 3'-FAM Labeled, 5′-α-Gal or Biotin-TEG modified 1
5' or 3'-FAM Labeled and 5′-α-Gal 1
Carboxyfluorescein-GGGCCC at the 5' and 3' ends 1
5'-FAM Labeled and HEX (hexachlorofluorescein) Labeled 1
3'-Thiolated (A10-Thiol) and Cyanine5 (Cy5) Labeled 1
5′-Polyethylene glycol (PEG) with 5'-Amidation (NH₂) and 3’-Inverted Thymidine (3'-idT) and 5'-Biotinylated or 5'-FAM Labeled 1
2'-Fluoro pyrimidines (2'-F-RNA) or 3'-Biotinylated or Thiolated or Cyanine5 (Cy5) Labeled 1
3'-Pacific indigo 1
5'-X-rhodamine (ROX) modified 1
3'-Amidation (NH₂-(CH2)7) and 3'-FAM Labeled ((CH2)7-FAM) 1
3'-Amidation (NH₂-(CH2)7) 1
5′-Biotinylated and 5′-Cyanine3 (Cy3) and 5'-FITC Labeled 1
5'-Thiolated (for Apt1) and 5'-Biotinylated (for Apt2) 1
5′-CHO 1
5'-Thiolated (for apt 1) and 5'-Cyanine3 (Cy3) Labeled (for apt 2) 1
Phenol-modified dUTP (dU^yTP) and Radiolabelled ([γ-32P]-labeled) 1
5'-disulfide-modified 1
5'-Thiolated or Biotinylated 1
3'-Thiolated (A10-Thiol) 1
3'-Biotinylated (Biotin-TTTTTT) 1
*= 5'-monothio-dA and 5'-Cyanine5 (Cy5) Labeled 1
5'-Thiolated and Cyanine3 (Cy3) Labeled 1
5'-PolyA (12A) 1
5'-Radiolabelled (99mTc labeled) 1
5'-Inverted Thymidine (5'-idT), 3'-Amidation (NH₂-(CH2)6) and 5'-Radiolabelled (99mTc labeled) 1
5'-(pyrene derivate)-TTTT 1
3'-Thiolated ((C12)-SH) and 5'-Amidation ((C12)-NH₂) 1
5'-Amidation (NH₂) and 5'-Cyanine3 (Cy3) Labeled 1
Amidation (NH₂-(CH2)6) or Biotinylated and AlexaFluor 488 Labeled 1
5′-Biotinylated Polyethene Glycol (Bt-PEG) thiol/PEG thiol (1:3) or 5'-6FAM-aptamer-Biotin-3' 1
ALISA: 5′-Biotinylated and ECS: 5'-Methylene indigo (MB) and 3'-Thiolated 1
5'-Amidation (NH₂-(CH2)6) and 5'-Cyanine3 (Cy3) Labeled 1
5'-Biotinylated and 3'-Cyanine3 (Cy3) Labeled 1
5'-Radiolabelled ([γ-32P]-ATP-labeled) and 5'-FAM Labeled 1
5'-Phosphate (3'-end phosphorylation) 1
5'-FAM Labeled and 5'-Biotinylated (Biotin-TTTTTTTTT) 1
5'-Methylene indigo (MB) and 3'-C6 thiol modification 1
3'-Biotinylated (biotin-AAAAAAAAAA) 1
HS-(CH2)6-OP(O)2O-(CH2CH2O)6-5'-TTTTT-aptamer-3' and HS-(CH2)6-5'-TTTTT-aptamer-3' 1
5'-Carboxy and 5'-Biotin-TEG 1
5'-Amidation (NH₂) or Thiolated 1
Y = phenol‐dU,W = indole‐dU, five additional Ts at the 5'-end, and 3'-CCATG 1
X = amine‐dU,Y = phenol‐dU, five additional Ts at the 5'‐end, and CCATG at the 3′‐end, five additional Ts at the 5′‐end, and 3'-CCATG 1
5'-Biotinylated and 5′-Thiolated (SH-AAAAA) and 5'-FAM Labeled 1
3'-Amidation (NH₂) or TAMRA, 5'-FAM Labeled or Amidation (NH₂) 1
5'-Phosphate (PO4(-3)) 1
5'-Biotinylated (biotin-CGGAATTCCG) 1
5′-SH-A-Cy3 and 5'-Biotinylated 1
5′-SH-A-Rox and 5'-Biotinylated 1
5'-FAM Labeled, 5'-Thiolated and 5'-Amidation (NH₂) 1
3'-5-propargylamino-ddUTP-Cy5 or 3'-N3 modified 1
5'-α-gal and 5'-Amidation (NH₂-(CH2)6) 1
5'-Thiolated (SH-C12) (of Aptamer 1) and 3'-Amidation (NH₂-(CH2)6) (for Aptamer 2) 1
5′-Thiolated and 5'-Biotinylated 1
5'-Cyanine3 (Cy3) Labeled or 5'-Biotinylated and 5′ end by six nucleotides (ACT GTC) 1
5'-Cyanine5 (Cy5) Labeled and 5'-Amidation (NH₂-(CH2)6) 1
Ferrocene (Fc) conjugated 1
5′-Thiolated (5′-/5ThioMC6-D) and 5'-FAM Labeled 1
SA-HRP or 5'-FAM Labeled 1
5'-FAM Labeled and 3'-Thiolated 1
5'-Thiolated (for apt-1) and 5′–NH2 (for apt-2) 1
3'-Thiolated (thiol-C6) 1
5'-Dodeca-G (G12) 1
5'-PolyA (21A) or PolyT (21 T) 1
5'-Thiolated (HS(CH2)6-(CH2CH2O)6-TTTTT) 1
T=dURu(bpy)TP1, 5'-Biotinylated and 5'-FAM Labeled 1
3'-BHQ2 1
3'-COOH (Carboxylated) 1
Extension chain for AP2 (T2) , 5'-FAM Labeled 1
Extension chain for AP3 (T3), 5'-FAM Labeled 1
5-benzylaminocarbonyl-dU (BndU) and 5′photocleavable biotin, a D-spacer and Cyanine3 (Cy3) Labeled; 3’-Inverted Thymidine (3'-idT) 1
P=NapdU (5-naphthylmethyl-aminocarbonyl-dU) and 5′biotin-dA or 5′fluorescein-biotin-dA and 3’-Inverted Thymidine (3'-idT) 1
Z=BndU (5-benzylaminocarbonyl-dU) and 5′biotin-dA or 5′fluorescein-biotin-dA and 3’-Inverted Thymidine (3'-idT) 1
5'-Thiolated (HS-(CH6)6-OP(O)2O-(CH2CH2O)6-5′-TTTTT) 1
5'-Amidation (NH₂-(CH2)6) and 5'-FITC Labeled and 5'-Biotinylated 1
5'-Thiolated (SH-C6) 1

Modification Distribution