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| AptBacDB_ID ⇅ | PMID/DOI ⇅ | Year ⇅ | Title ⇅ | Aptamer name ⇅ | Sequence (5′ to 3′) ⇅ | Length ⇅ | Library ⇅ | Type ⇅ | Target Organism ⇅ | Target ⇅ | Objective/Mechanism ⇅ | Outcome/Inhibitory effect ⇅ | No. of selection round SELEX ⇅ | Determination of affinity method ⇅ | Kd value ⇅ | Activity Role ⇅ | Method ⇅ | Modification ⇅ | Cytotoxicity (cell viability) ⇅ | Stability⇅ | Potential Candidate ⇅ | Half-life ⇅ | Patent ⇅ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ABdb_1040 | 29408200 | 2018 | Highly affine and selective aptamers against cholera toxin as capture elements in magnetic bead-based sandwich ELAA | CT916 | CATCCGTCACACCTGCTC-GGCAAAAAGGATTGCCCAGGTCTGCTGTCTAGCCGGATTC-GGTGTTGGCTCCCGTATC | 76 | 5'-CATCCGTCACACCTGCTC-N40-GGTGTTGGCTCCCGTATC-3' | ssDNA | Vibrio Cholerae | Cholera toxin (AB5-type toxin composed of a donut-shaped homopentameric B subunit (CT-B)) | Identify aptamers against and develop an MB-based sandwich ELAA to detect CT-B from spiked tap water. | Detection limits of 2.1 ng/ml in buffer and 2.4 ng/ml in tap water, with a linear range from about 1 ng/ml to 1000 ng/ml. | 12 | Bead-based Affinity Chromatography | 48.5 ± 0.5 nM | Biosensor | SELEX | Amidation (NH₂-(CH2)6) or Biotinylated and AlexaFluor 488 Labeled | N/A | N/A | Best Candidate | N/A | N/A |