Modification : 3'-Amidation (NH₂) and 5'-FITC Labeled

Total records found: 2

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AptBacDB_ID ⇅	PMID/DOI ⇅	Year ⇅	Title ⇅	Aptamer name ⇅	Sequence (5′ to 3′) ⇅	Length ⇅	Library ⇅	Type ⇅	Target Organism ⇅	Target ⇅	Objective/Mechanism ⇅	Outcome/Inhibitory effect ⇅	No. of selection round SELEX ⇅	Determination of affinity method ⇅	Kd value ⇅	Activity Role ⇅	Method ⇅	Modification ⇅	Cytotoxicity (cell viability) ⇅	Stability⇅	Potential Candidate ⇅	Half-life ⇅	Patent ⇅
ABdb_0823	28069377	2017	Development of an aptamer-ampicillin conjugate for treating biofilms	Aptamer 3	GGGAGCTCAGAATAAACGCTCAA-GGCAGGACAACAGCGTGTAGTATCAGCTTACGGTG-TTCGACATGAGGCCCGGATC	78	N/A	ssDNA	Salmonella Choleraesuis	Flagella	Aptamer-ampicillin conjugate (Apt3-Amp) to inhibit biofilm formation.	Biofilms containing the conjugate had the lowest survival ratio (37.22 ± 1.12%) compared with control conjugates.	14	Fluorescence Spectroscopy	41 ± 2 nM	Therapeutics	Whole Cell-SELEX	3'-Amidation (NH₂) and 5'-FITC Labeled	N/A	N/A	Best Candidate	N/A	N/A
ABdb_1548	34396009	2021	DNA Aptamer-Conjugated Magnetic Graphene Oxide for Pathogenic Bacteria Aggregation: Selective and Enhanced Photothermal Therapy for Effective and Rapid Killing	MRSA aptamer	ATCCAGACGTGACGCAGC-ATGCGGTTGGTTGCGGTTGGGCATGATGTATTTCTGTG-TGGACACGGTGGCTTAGTA	75	5'-ATCCAGACGTGACGCAGC-N38-TGGACACGGTGGCTTAGTA-3'	ssDNA	Methicillin-resistant Staphylococcus aureus (MRSA)	Whole cell	Apt@MGO nanoplatform for selective and rapid eradication of MRSA under NIR laser irradiation.	Apt@MGO resulted in ∼78% MRSA and over >97% MRSA cell inactivation in dispersed and aggregated states, respectively, under 200 seconds of exposure to NIR irradiation (808 nm, 1.1 W cm–2).	N/A	N/A	N/A	Targeted Delivery/Therapeutics	N/A	3'-Amidation (NH₂) and 5'-FITC Labeled	The aptamer itself did not cause any cell activation when incubated with MRSA cells, and also under no NIR laser illumination.	N/A	N/A	N/A	N/A