AptBacterialDB

Modification : 5'-FAM Labeled and 5'-Amidation (NH₂)

Total records found: 7

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AptBacDB_ID ⇅ PMID/DOI ⇅ Year ⇅ Title ⇅ Aptamer name ⇅ Sequence (5′ to 3′) ⇅ Length ⇅ Library ⇅ Type ⇅ Target Organism ⇅ Target ⇅ Objective/Mechanism ⇅ Outcome/Inhibitory effect ⇅ No. of selection round SELEX ⇅ Determination of affinity method ⇅ Kd value ⇅ Activity Role ⇅ Method ⇅ Modification ⇅ Cytotoxicity (cell viability) ⇅ Stability⇅ Potential Candidate ⇅ Half-life ⇅ Patent ⇅
ABdb_1672 358504612022Aptamer decorated emodin nanoparticles-assisted delivery of dermcidin-derived peptide DCD-1L: Photoactive bio-theragnostic agent for Enterococcus faecalis biofilm destructionAptamerTAGGGAAGAGAAGGACATATGATACTGGCCTTGACACCCTGTTGTGGCTTGATGACAATAACATTGACTAGTACATGACCACTTGA86N/AssDNAEnterococcus FaecalisWhole cellApt@EmoNp-DCD-1L that binds E. faecalis, enabling targeted delivery of emodin nanoparticles and DCD-1L for anti-biofilm activity.aPDT using Apt@EmoNp-DCD-1L caused ≈99.99% reduction of E. faecalis viability and strong biofilm disruption at sub-MIC concentrations (7.8 and 15.6 µM).N/AN/AN/ATargeted Delivery/TherapeuticsN/A5'-FAM Labeled and 5'-Amidation (NH₂)N/AN/AN/AN/AN/A
ABdb_1921 400531472025Fluorescent aptasensor for detection of Salmonella typhimurium using boric acid-functionalized terbium metal-organic framework and magnetic nanoparticlesAptamerTAGGGAAGAGAAGGACATATGATCAGGAGTCATGCTACCACTGGTGATTACGCCTCGCTCAGCTTGACTAGTACATGACCACTTGA86N/AssDNASalmonella Typhimurium (S. Typhimurium) (MTCC 3232)Whole cellA fluorescent detection platform was developed using boric acid-functionalized terbium metal–organic framework (BA-Tb-MOF) and carboxyl-modified magnetic nanoparticles (MNPs) to identify S. typhimurium.Showed an inverse linear relationship within the range of 10(1)–10(9) CFU/mL, and the detection limit was 4 CFU/mL.N/AN/AN/ABiosensorWhole Cell-SELEX5'-FAM Labeled and 5'-Amidation (NH₂)N/AN/AN/AN/AN/A
ABdb_2124 343991932021Aptamer-superparamagnetic nanoparticles capture coupling siderophore-Fe3+ scavenging actuated with carbon dots to confer an "off-on" mechanism for the ultrasensitive detection of Helicobacter pyloriHp-1N/AN/A5'-TGGACCTTGCGATTGCGATTGACAGC-40N-GCAGACATGAGTCTCAGGAC-3'ssDNAHelicobacter Pylori (ATCC 700392)Whole cellAptamer-modified superparamagnetic nanoparticles (SPMNPs) are used to develop a triple-module biosensor to capture H. pylori.Exhibited a wide detection range of 10-10(7) CFU/mL and a limit of detection (LOD) as low as 1 CFU/mL.10Fluorescence Spectroscopy36.91 ± 11.1 nMBiosensorSELEX5'-FAM Labeled and 5'-Amidation (NH₂)N/AN/ABest CandidateN/AN/A
ABdb_2125 343991932021Aptamer-superparamagnetic nanoparticles capture coupling siderophore-Fe3+ scavenging actuated with carbon dots to confer an "off-on" mechanism for the ultrasensitive detection of Helicobacter pyloriHp-2N/AN/A5'-TGGACCTTGCGATTGCGATTGACAGC-40N-GCAGACATGAGTCTCAGGAC-3'ssDNAHelicobacter Pylori (ATCC 700392)Whole cellAptamer-modified superparamagnetic nanoparticles (SPMNPs) capture H. pylori.N/A10Fluorescence Spectroscopy46.31 ± 11.31 nMBiosensorSELEX5'-FAM Labeled and 5'-Amidation (NH₂)N/AN/AN/AN/AN/A
ABdb_2126 343991932021Aptamer-superparamagnetic nanoparticles capture coupling siderophore-Fe3+ scavenging actuated with carbon dots to confer an "off-on" mechanism for the ultrasensitive detection of Helicobacter pyloriHp-3N/AN/A5'-TGGACCTTGCGATTGCGATTGACAGC-40N-GCAGACATGAGTCTCAGGAC-3'ssDNAHelicobacter Pylori (ATCC 700392)Whole cellAptamer-modified superparamagnetic nanoparticles (SPMNPs) capture H. pylori.N/A10Fluorescence Spectroscopy60.76 ± 11.69 nMBiosensorSELEX5'-FAM Labeled and 5'-Amidation (NH₂)N/AN/AN/AN/AN/A
ABdb_2127 343991932021Aptamer-superparamagnetic nanoparticles capture coupling siderophore-Fe3+ scavenging actuated with carbon dots to confer an "off-on" mechanism for the ultrasensitive detection of Helicobacter pyloriHp-4N/AN/A5'-TGGACCTTGCGATTGCGATTGACAGC-40N-GCAGACATGAGTCTCAGGAC-3'ssDNAHelicobacter Pylori (ATCC 700392)Whole cellAptamer-modified superparamagnetic nanoparticles (SPMNPs) capture H. pylori.N/A10Fluorescence Spectroscopy41.57 ± 16.18 nMBiosensorSELEX5'-FAM Labeled and 5'-Amidation (NH₂)N/AN/AN/AN/AN/A
ABdb_2128 343991932021Aptamer-superparamagnetic nanoparticles capture coupling siderophore-Fe3+ scavenging actuated with carbon dots to confer an "off-on" mechanism for the ultrasensitive detection of Helicobacter pyloriHp-5N/AN/A5'-TGGACCTTGCGATTGCGATTGACAGC-40N-GCAGACATGAGTCTCAGGAC-3'ssDNAHelicobacter Pylori (ATCC 700392)Whole cellAptamer-modified superparamagnetic nanoparticles (SPMNPs) capture H. pylori.N/A10Fluorescence Spectroscopy67.74 ± 10.24 nMBiosensorSELEX5'-FAM Labeled and 5'-Amidation (NH₂)N/AN/AN/AN/AN/A