97
|
Thymosin b15 (Tb15)
|
Protein
|
Humans
|
Upregulated in PCa
|
Diagnostic
|
Untreated Prostate Cancer Vs Controls
|
p<0.001
|
Urine
|
15666387
|
98
|
Thymosin b15 (Tb15)
|
Protein
|
Humans
|
Upregulated in PCa
|
Diagnostic
|
ADT treated Prostate Cancer Vs Controls
|
p=0.001
|
Urine
|
15666387
|
113
|
PCaP Polypeptide Panel (PCAPP)
|
Protein
|
Humans
|
Differentially Expressed in Prostate Cancer
|
Diagnostic
|
Prostate Cancer Vs Healthy Controls
|
p<0.05
|
Urine
|
19759844
|
117
|
ααCTX
|
Protein
|
Humans
|
Upregulated in Bone Metastatis PCa
|
Prognostic
|
Bone Metastatis Prostate Cancer Vs No Bone Metastatis Prostate Cancer
|
p<0.05
|
Urine
|
16434583
|
118
|
ββCTX
|
Protein
|
Humans
|
Upregulated in Bone Metastatis PCa
|
Prognostic
|
Bone Metastatis Prostate Cancer Vs No Bone Metastatis Prostate Cancer
|
p<0.05
|
Urine
|
16434583
|
119
|
NTx
|
Protein
|
Humans
|
Upregulated in Bone Metastatis PCa
|
Prognostic
|
Bone Metastatis Prostate Cancer Vs No Bone Metastatis Prostate Cancer
|
p<0.05
|
Urine
|
16434583
|
134
|
Fusion Status of TMPRSS2-ERG
|
mRNA
|
Humans
|
Fusion of the genes in Positive Biopsy PCa
|
Prognostic
|
Positive Vs Negative Biopsies for PCa
|
NA
|
Urine
|
17785564
|
135
|
PCA3
|
mRNA
|
Humans
|
Upregulated in Positive Biopsy PCa
|
Prognostic
|
Positive Vs Negative Biopsies for PCa
|
NA
|
Urine
|
17785564
|
136
|
Fusion Status of (TMPRSS2-ERG)+PCA3
|
mRNA
|
Humans
|
Fused/ Upregulated in PCa
|
Diagnostic
|
Positive Vs Negative Biopsies for PCa
|
NA
|
Urine
|
17785564
|
243
|
SPINK1
|
mRNA
|
Humans
|
Upregulated in PCa
|
Diagnostic
|
Normal Vs Prostate Cancer
|
p=0.0002
|
Urine
|
18245462
|
244
|
GOLPH2
|
mRNA
|
Humans
|
Upregulated in PCa
|
Diagnostic
|
Normal Vs Cancer
|
p=0.0002
|
Urine
|
18245462
|
245
|
PCA3
|
mRNA
|
Humans
|
Upregulated in PCa
|
Diagnostic
|
Normal Vs Cancer
|
p=0.001
|
Urine
|
18245462
|
246
|
SPINK1, PCA3, GOLPH2, TMPRSS2:ERG
|
mRNA
|
Humans
|
Upregulated in PCa
|
Diagnostic
|
Normal Vs Cancer
|
p=1.91E-11
|
Urine
|
18245462
|
247
|
SPINK1, PCA3, GOLPH2, TMPRSS2:ERG
|
mRNA
|
Humans
|
Upregulated in PCa
|
Diagnostic
|
Normal Vs Cancer
|
p=1.91E-11
|
Urine
|
18245462
|
414
|
4-OHE1(E2)-1-N7Gua
|
Metabolites
|
Humans
|
Upregulated (PCA median: 0.7pmol/ml vs Control median: 0.3pmol/ml)
|
Diagnostic
|
Prostate Cancer Vs Controls
|
p=0.0004
|
Urine
|
18816637
|
415
|
4-OHE1-1-N3Ade
|
Metabolites
|
Humans
|
Upregulated (PCA median: 0.4pmol/ml vs Control median: 0.2pmol/ml)
|
Diagnostic
|
Prostate Cancer Vs Controls
|
p=0.056
|
Urine
|
18816637
|
416
|
2-OHE1-6-N3Ade
|
Metabolites
|
Humans
|
Upregulated (PCA median: 0.2pmol/ml vs Control median: 0pmol/ml)
|
Diagnostic
|
Prostate Cancer Vs Controls
|
p=0.0014
|
Urine
|
18816637
|
444
|
Differential display 3 (DD3/PCA3)
|
mRNA
|
Humans
|
Upregulated in PCa (37 fold)
|
Diagnostic
|
Benign prostatic hyperplasia (BPH) Vs prostate cancer (PCa)
|
p=0.0001
|
Urine
|
19489685
|
445
|
Urinary PSA
|
mRNA
|
Humans
|
Upregulated
|
Diagnostic
|
Benign prostatic hyperplasia (BPH) Vs prostate cancer (PCa)
|
p=0.0001
|
Urine
|
19489685
|
446
|
DD3 +PSA
|
mRNA
|
Humans
|
Upregulated
|
Diagnostic
|
Benign prostatic hyperplasia (BPH) Vs prostate cancer (PCa)
|
p<0.0001
|
Urine
|
19489685
|
484
|
PSA+MMP-2+ AMACR + Methylation Status of (GSTP1 or RASSF1A)
|
Protein + DNA
|
Humans
|
Upregulated and Hypermethylated in PCa
|
Diagnostic
|
Prostate Cancer Vs No Tumor
|
p=0.036
|
Urine and Serum
|
20632177
|
485
|
Methylation Status of GSTP1 or RASSF1A
|
Methylation
|
Humans
|
HyperMethylated in PCa
|
Diagnostic
|
Prostate Cancer Vs No Tumor
|
p<0.05
|
Urine
|
20632177
|
486
|
PSGR (Prostate-Specific G-protein Coupled Receptor)
|
mRNA
|
Humans
|
Upregulated
|
Diagnostic
|
Benign Vs Prostate Cancer
|
p=0.008
|
Urine
|
20672322
|
487
|
PCA3 (Prostate Cancer Gene 3)
|
mRNA
|
Humans
|
Upregulated
|
Diagnostic
|
Benign Vs Prostate Cancer
|
p<0.001
|
Urine
|
20672322
|
488
|
PSGR + PCA3
|
mRNA
|
Humans
|
Upregulated
|
Diagnostic
|
Benign Vs Prostate Cancer
|
NA
|
Urine
|
20672322
|
489
|
PCA3 (Prostate Cancer Gene 3)
|
mRNA
|
Humans
|
Upregulated in Positive Biopsy
|
Diagnostic
|
Positive PCa Biopsy Vs Negative PCa Biopsy
|
p <0.0001
|
Urine
|
20850153
|
490
|
Age+ Family History+ PCA3 + %fPSA+ Prostate Volume+ sPSA
|
mRNA
|
Humans
|
Upregulated in Positive Biopsy
|
Diagnostic
|
Positive PCa Biopsy Vs Negative PCa Biopsy
|
p <0.0001
|
Urine
|
20850153
|
491
|
Age+ Family History+ PCA3 + %fPSA+ Prostate Volume+ sPSA
|
mRNA
|
Humans
|
Upregulated in Positive Biopsy
|
Diagnostic
|
Positive PCa Biopsy Vs Negative PCa Biopsy
|
p <0.0001
|
Urine
|
20850153
|
510
|
TRPM8 (transient receptor potential member 8)
|
mRNA
|
Humans
|
Upregulated in Metastatis
|
Diagnostic
|
Healthy Vs Metastatic
|
p<0.0001
|
Urine
|
20043080
|
543
|
PCA3
|
mRNA
|
Humans
|
Differentially Expressed
|
Diagnostic
|
Cancer Vs No Malignancy (PSA Range: 4-10)
|
Univariate: p=0; Multivariate: p=0.02
|
Urine
|
20957673
|
544
|
TMPRSS2: ERG
|
mRNA
|
Humans
|
Differentially Expressed
|
Diagnostic
|
Cancer Vs No Malignancy (PSA Range: 4-10)
|
Univariate: p=0.002; Multivariate: p=0.028
|
Urine
|
20957673
|
545
|
Annexin A3
|
Protein
|
Humans
|
Differentially Expressed
|
Diagnostic
|
Cancer Vs No Malignancy (PSA Range: 4-10)
|
Univariate: p=0; Multivariate: p=0.027
|
Urine
|
20957673
|
546
|
Sarcosine
|
Metabolites
|
Humans
|
Differentially Expressed
|
Diagnostic
|
Cancer Vs No Malignancy (PSA Range: 4-10)
|
Univariate: p=0.011; Multivariate: p=0.015
|
Urine
|
20957673
|
547
|
PCA3
|
mRNA
|
Humans
|
Differentially Expressed
|
Diagnostic
|
Cancer Vs No Malignancy
|
Univariate: p=0; Multivariate: p=0.02
|
Urine
|
20957673
|
548
|
TMPRSS2: ERG
|
mRNA
|
Humans
|
Differentially Expressed
|
Diagnostic
|
Cancer Vs No Malignancy
|
Univariate: p=0.002; Multivariate: p=0.028
|
Urine
|
20957673
|
549
|
Annexin A3
|
Protein
|
Humans
|
Differentially Expressed
|
Diagnostic
|
Cancer Vs No Malignancy
|
Univariate: p=0.002; Multivariate: p=0.027
|
Urine
|
20957673
|
550
|
Sarcosine
|
Metabolites
|
Humans
|
Differentially Expressed
|
Diagnostic
|
Cancer Vs No Malignancy
|
Univariate: p=0.011; Multivariate: p=0.015
|
Urine
|
20957673
|
598
|
Engrailed-2 (EN2)
|
Protein
|
Humans
|
Upregulated in PCa
|
Diagnostic
|
Prostate Cancer Vs Controls
|
p<0.0001
|
Urine
|
21364037
|
644
|
PSMA
|
mRNA
|
Humans
|
Downregulated in PCa
|
Diagnostic
|
Prostate Cancer Vs Benign
|
p=0.016
|
Urine
|
21520154
|
645
|
PSGR
|
mRNA
|
Humans
|
Upregulted in PCa
|
Diagnostic
|
Prostate Cancer Vs Benign
|
p<0.001
|
Urine
|
21520154
|
646
|
PCA3
|
mRNA
|
Humans
|
Upregulted in PCa
|
Diagnostic
|
Prostate Cancer Vs Benign
|
p=0.018
|
Urine
|
21520154
|
647
|
PSMA + PSGR + PCA3
|
mRNA
|
Humans
|
Differentially Expressed
|
Diagnostic
|
Prostate Cancer Vs Benign
|
NA
|
Urine
|
21520154
|
648
|
PSMA + PSGR + PCA3 + PSA
|
mRNA
|
Humans
|
Differentially Expressed
|
Diagnostic
|
(Prostate Cancer Vs Benign) with PSA in range 4-10ng/ml
|
NA
|
Urine
|
21520154
|
649
|
PSMA
|
mRNA
|
Humans
|
Downregulated in PCa
|
Diagnostic
|
(Prostate Cancer Vs Benign) with PSA in range 4-10ng/ml
|
p=0.003
|
Urine
|
21520154
|
650
|
PSGR
|
mRNA
|
Humans
|
Upregulted in PCa
|
Diagnostic
|
(Prostate Cancer Vs Benign) with PSA in range 4-10ng/ml
|
p= 0.009
|
Urine
|
21520154
|
651
|
PCA3
|
mRNA
|
Humans
|
Upregulted in PCa
|
Diagnostic
|
(Prostate Cancer Vs Benign) with PSA in range 4-10ng/ml
|
p=0.025
|
Urine
|
21520154
|
652
|
PSMA + PSGR + PCA3
|
mRNA
|
Humans
|
Differentially Expressed
|
Diagnostic
|
(Prostate Cancer Vs Benign) with PSA in range 4-10ng/ml
|
NA
|
Urine
|
21520154
|
658
|
PCA3
|
mRNA
|
Humans
|
Differentially Expressed
|
Diagnostic
|
Prostate Cancer Vs No Prostate cancer
|
p=0.001
|
Urine
|
21600800
|
659
|
PSA
|
mRNA
|
Humans
|
Upregulated in PCa
|
Diagnostic
|
Prostate Cancer Vs No Prostate cancer
|
p=0.019
|
Urine
|
21600800
|
660
|
TMPRSS2:ERG
|
mRNA
|
Humans
|
Differentially Expressed
|
Diagnostic
|
Prostate Cancer Vs No Prostate cancer
|
p=0.001
|
Urine
|
21600800
|
661
|
PSA +PCA3 + TMPRSS2:ERG
|
mRNA
|
Humans
|
Differentially Expressed
|
Diagnostic
|
Prostate Cancer Vs No Prostate cancer
|
NA
|
Urine
|
21600800
|
662
|
TMPRSS2:ERG+ PCA3
|
mRNA
|
Humans
|
Differentially Expressed
|
Diagnostic
|
Prostate Cancer Vs No Prostate cancer
|
NA
|
Urine
|
21600800
|
663
|
Propenoic acid+ Pyrimidine+ Dihyroxybutanoic acid+Creatinine+ Purine+ Glucopyranoside+ Ribofuranoside+Xylonic acid=Xylopyranose
|
Metabolites
|
Humans
|
Upregulated in PCA: (Propenoic acid, Dihyroxybutanoic acid, Creatinine and Xylonic acid); Downregulated in PCA: (Pyrimidine, Creatinine, Purine, Glucopyranoside, Ribofuranoside, Xylopyranose)
|
Diagnostic
|
Prostate Cancer Vs Healthy Men
|
p<0.05
|
Urine
|
21626193
|
664
|
Dihyroxybutanoic acid + Pyrimidine + Xylonic acid + Xylopyranose + Ribofuranoside
|
Metabolites
|
Humans
|
Upregulated in PCA: (Dihyroxybutanoic acid, Xylonic acid); Downregulated in PCA: (Pyrimidine, Xylopyranose, Ribofuranoside)
|
Diagnostic
|
PCa Vs Non Cancerous (healthy+BPH)
|
p<0.05
|
Urine
|
21626193
|
688
|
PCA3
|
mRNA
|
Humans
|
Upregulated in Prostate Cancer
|
Diagnostic
|
Prostate Cancer Vs Non- Prostate Cancer
|
p<0.001
|
Urine
|
21788966
|
689
|
PCA3
|
mRNA
|
Humans
|
Differentially Expressed
|
Diagnostic
|
Prostate Cancer Vs Non- Prostate Cancer
|
p=0.04
|
Urine
|
21788966
|
690
|
AMACR
|
mRNA
|
Humans
|
Differentially Expressed
|
Diagnostic
|
Prostate Cancer Vs Non- Prostate Cancer
|
p=0.04
|
Urine
|
21788966
|
691
|
Multiplex Model (PCA3+ AMACR+ SPINK1+ EZH2+ GOLM1+ TRPM8 + MSMB + Serum PSA)
|
mRNA
|
Humans
|
Differentially Expressed
|
Diagnostic
|
Prostate Cancer Vs Non- Prostate Cancer
|
p<0.001
|
Urine
|
21788966
|
692
|
Quadriplex Model (TRPM8 + MSMB+ PCA3+ AMACR)
|
mRNA
|
Humans
|
Differentially Expressed
|
Diagnostic
|
Prostate Cancer Vs Non- Prostate Cancer
|
p<0.001
|
Urine
|
21788966
|
693
|
Triplex Model (TRPM8 + MSMB+AMACR)
|
mRNA
|
Humans
|
Differentially Expressed
|
Diagnostic
|
Prostate Cancer Vs Non- Prostate Cancer
|
p<0.001
|
Urine
|
21788966
|
694
|
Duplex Model (TRPM8 + MSMB)
|
mRNA
|
Humans
|
Differentially Expressed
|
Diagnostic
|
Prostate Cancer Vs Non- Prostate Cancer
|
p=0.01
|
Urine
|
21788966
|
695
|
AMACR
|
mRNA
|
Humans
|
Upregulated in locally advanced cancers
|
Prognostic
|
localized Vs locally advanced cancers
|
p= 0.044
|
Urine
|
21788966
|
696
|
EZH2
|
mRNA
|
Humans
|
Upregulated in locally advanced cancers
|
Prognostic
|
localized Vs locally advanced cancers
|
p= 0.022
|
Urine
|
21788966
|
697
|
EZH2
|
mRNA
|
Humans
|
Upregulated in Intermediate and further upregulated in High Risk Group
|
Prognostic
|
Low Vs Intermediate Vs High Risk Group
|
High vs low-risk group patients (P = 0.002), intermediate vs low risk group patients (P = 0.044)
|
Urine
|
21788966
|
702
|
Methylation Status of (RARB or GSTP1 or RASSF1)
|
Methylation
|
Humans
|
Hypermethylated in Cancer
|
Prognostic
|
Methylation in Patients with PCa
|
NA
|
Urine
|
21822036
|
704
|
Methylation Status of RARB
|
Methylation
|
Humans
|
Hypermethylated in Gleason Score 7 (PMR>=50)
|
Prognostic
|
Gleason Score 6 Vs Gleason Score 7
|
p=0.01
|
Urine
|
21822036
|
833
|
APOD; C1QTNF3; CD27; CFB; CFH; CLU; CRABP1; DDAH2; FTL; IGSF8; ITIH4l; LGALS3; LYZ; MGAT5; PECAM1; RBP4; RECK; SELENBP1; SLIT2;
|
mRNA
|
Humans
|
(1.358 fold) Upregulated in PCa [APOD (2.803 fold) ; C1QTNF3 (1.100 fold); CD27 (1.183 fold); CFB (3.231 fold); CFH (1.381 fold); CLU (1.638 fold); CRABP1 (1.477 fold) ; DDAH2 (1.152 fold) ; FTL (1.718 fold); IGSF8 (1.358 fold) ; ITIH4l (1.215 fold) ; LGALS3 (4.121 fold) ; LYZ (2.093 fold) ; MGAT5 (1.112 fold); PECAM1 (2.404 fold) ; RBP4 (1.872 fold); RECK (2.569 fold) ; SELENBP1 (1.327 fold) ; SLIT2 (1.848 fold)]
|
Diagnostic
|
Prostate Cancer Vs Normal controls
|
p<0.001
|
Urine
|
22194848
|
840
|
miRNA - 107
|
miRNA
|
Humans
|
Upregulated in Pca
|
Diagnostic
|
Benign Vs Prostate Cancer
|
p=0.001
|
Urine
|
22240788
|
841
|
miRNA - 574-3p
|
miRNA
|
Humans
|
Upregulated in PCa
|
Diagnostic
|
Benign Vs Prostate Cancer
|
p=0.012
|
Urine
|
22240788
|
906
|
Fusion status of TMPRSS2-ERG and TERT expression
|
mRNA
|
Humans
|
TMPRSS2–ERG and TERT-negative tumors had significantly lower rate of recurrence
|
Prognostic
|
Biochemical Recurrence Free Survival
|
p=0.025
|
Urine
|
22505341
|
910
|
PCA3
|
Protein
|
Humans
|
Upreregulated in PCa
|
Diagnostic
|
PCa VS No PCa group
|
p< 0.001
|
Urine
|
22542564
|
918
|
PCA3
|
mRNA
|
Humans
|
Upregulated in PCa
|
Diagnostic
|
Prostate Cancer Vs No Cancer (@ first negative biopsy) [Group A]
|
NA
|
Urine
|
22564540
|
919
|
PCA3
|
mRNA
|
Humans
|
Upregulated in PCa
|
Diagnostic
|
Prostate Cancer Vs No Cancer (@ first negative biopsy) [Group B]
|
NA
|
Urine
|
22564540
|
962
|
Prostate Cancer Antigen 3 (PCA3)
|
mRNA
|
Humans
|
Upregulated in PCa [No PCa: 32 (13.5–68) Vs PCa 50 (34–83)]
|
Diagnostic
|
PCa Vs No-PCa
|
p=0.001
|
Urine
|
22821756
|
963
|
PCA3 + phi
|
mRNA
|
Humans
|
Upregulated in PCa
|
Diagnostic
|
PCa Vs No-PCa
|
p=0.001
|
Urine + Serum
|
22821756
|
988
|
Zinc α2-glycoprotein (ZAG)
|
Protein
|
Humans
|
Upregulated in PCa
|
Diagnostic
|
PCA VS No PCA group
|
p=0.05
|
Urine
|
23020913
|
989
|
Zinc α2-glycoprotein (ZAG) + PSA
|
Protein
|
Humans
|
Upregulated in PCa
|
Diagnostic
|
PCA VS No PCA group
|
p=0.05
|
Urine + Serum
|
23020913
|
1020
|
PCA3 score >= 25
|
mRNA
|
Humans
|
PCA3 Score upregulated in PCa (No PCa: 24; Pca: 60)
|
Diagnostic
|
PCa Vs No PCA group
|
p<0.001
|
Urine
|
23201468
|
1021
|
TMPRSS2-ERG (v-ets erythroblastosis virus E26 oncogene homolog) >= 10
|
mRNA
|
Humans
|
TMPRSS2-ERG fusion upregulated in PCa (No PCa: 15; Pca: 46)
|
Diagnostic
|
PCa Vs No PCA group
|
p<0.001
|
Urine
|
23201468
|
1022
|
TMPRSS2-ERG (v-ets erythroblastosis virus E26 oncogene homolog) >= 10
|
mRNA
|
Humans
|
NA
|
Prognostic
|
Gleason Score <7 Vs Gleason score ≥ 7
|
p<0.001
|
Urine
|
23201468
|
1023
|
TMPRSS2-ERG
|
mRNA
|
Humans
|
NA
|
Prognostic
|
Tumor Stage (T3-T4)
|
p = 0.023
|
Urine
|
23201468
|
1068
|
AMBP precursor (AMBPf1)
|
Protein
|
Humans
|
Upregulated in Prostate Cancer
|
Diagnostic
|
Prostate Cancer Vs Controls
|
p=0.005
|
Urine
|
23417432
|
1069
|
AMBP precursor (AMBPf2)
|
Protein
|
Humans
|
Upregulated in Prostate Cancer
|
Diagnostic
|
Prostate Cancer Vs Controls
|
p=0.004
|
Urine
|
23417432
|
1070
|
Saposin
|
Protein
|
Humans
|
Upregulated in Prostate Cancer
|
Diagnostic
|
Prostate Cancer Vs Controls
|
p=0.002
|
Urine
|
23417432
|
1071
|
AMBP precursor (AMBPf2)
|
Protein
|
Humans
|
Upregulated in Prostate Cancer
|
Diagnostic
|
Prostate Cancer Vs Benign Prostatic Hyperplasia
|
p=0.004
|
Urine
|
23417432
|
1072
|
Inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4)
|
Protein
|
Humans
|
Upregulated in Prostate Cancer
|
Diagnostic
|
Prostate Cancer Vs Controls
|
p=0.006
|
Urine
|
23417432
|
1079
|
PCA3
|
mRNA
|
Humans
|
Upregulated with High Gleason Score
|
Prognostic
|
Low Gleason Score Vs high Gleason Score (≥7)
|
p=0.02
|
Urine
|
23515404
|
1080
|
TMPRSS2:ERG
|
mRNA
|
Humans
|
Upregulated with High Gleason Score
|
Prognostic
|
Low Gleason Score Vs high Gleason Score (≥7)
|
p=0.02
|
Urine
|
23515404
|
1081
|
PCA3 + TMPRSS2:ERG
|
mRNA
|
Humans
|
Upregulated with High Gleason Score
|
Prognostic
|
Low Gleason Score Vs high Gleason Score (≥7)
|
NA
|
Urine
|
23515404
|
1082
|
PCA3
|
mRNA
|
Humans
|
Upregulated in Positive Biopsy
|
Diagnostic
|
Positive Vs Negative Biopsy
|
P =0.01
|
Urine
|
23515404
|
1083
|
TMPRSS2:ERG
|
mRNA
|
Humans
|
Upregulated in Positive Biopsy
|
Diagnostic
|
Positive Vs Negative Biopsy
|
P =0.001
|
Urine
|
23515404
|
1084
|
PCA3 + TMPRSS2:ERG + PSA
|
mRNA
|
Humans
|
Upregulated with High Gleason Score
|
Prognostic
|
Low Gleason Score Vs high Gleason Score (≥7)
|
NA
|
Urine
|
23515404
|
1175
|
PCA3
|
mRNA
|
Humans
|
Upregulated in PCa
|
Diagnostic
|
Prostate Cancer Vs No evidence of Maligancy
|
p <0.001
|
Urine
|
23861782
|
1213
|
Methylation Status of HIST1H4K
|
Methylation
|
Humans
|
Hypermethylated in PCa
|
Diagnostic
|
Prostate Cancer Vs Normal Prostate
|
p<0.0001
|
Urine
|
24065480
|
1214
|
PCA3
|
mRNA
|
Humans
|
Upregulated in PCa
|
Diagnostic
|
Prostate Cancer Vs Normal Prostate
|
NA
|
Urine
|
24080222
|
1215
|
PCA3 + Multiparametric MRI
|
Others
|
Humans
|
PCA3 Upregulated in PCa
|
Diagnostic
|
Prostate Cancer Vs Normal Prostate
|
NA
|
Urine + Technique
|
24080222
|
1221
|
β-Microseminoprotein
|
Protein
|
Humans
|
Downregulated in PCa
|
Diagnostic
|
Prostate Cancer Vs Other Prostatic Conditions
|
p = 0.01
|
Urine
|
24115268
|
1222
|
β-Microseminoprotein + PSA
|
Protein
|
Humans
|
Downregulated in PCa
|
Diagnostic
|
Prostate Cancer Vs Other Prostatic Conditions
|
β-Microseminoprotein: [p = 0.01]
|
Urine
|
24115268
|
1229
|
miR-205
|
miRNA
|
Humans
|
Downregulated in PCa
|
Diagnostic
|
Prostate Cancer Vs Healthy Controls
|
p<0.001
|
Urine
|
24167554
|
1230
|
miR-214
|
miRNA
|
Humans
|
Downregulated in PCa
|
Diagnostic
|
Prostate Cancer Vs Healthy Controls
|
p<0.001
|
Urine
|
24167554
|
1231
|
miR-205+ miR-214
|
miRNA
|
Humans
|
Downregulated in PCa
|
Diagnostic
|
Prostate Cancer Vs Healthy Controls
|
p<0.001
|
Urine
|
24167554
|
1240
|
Prostate cancer antigen 3 [PCA3]
|
mRNA
|
Humans
|
Upregulated in PCa
|
Diagnostic
|
Prostate Cancer Vs No Prostate Cancer
|
NA
|
Urine
|
24211598
|
1241
|
PCA3 /PSA ratio (PCa antigen 3 [PCA3])
|
mRNA
|
Humans
|
Upregulated in PCa
|
Diagnostic
|
Prostate Cancer Vs No Prostate Cancer
|
NA
|
Urine
|
24211598
|
1247
|
Anterior gradient 2 [AGR2]
|
Protein
|
Humans
|
Upregulated in PCa
|
Diagnostic
|
Prostate Cancer Vs No Prostate Cancer
|
p = 0.026
|
Urine
|
24251762
|
1251
|
Active Hepatocyte Growth Factor [aHGF]
|
Protein
|
Humans
|
Upregulated in PCa: [Controls: 111.3; Localised PCa: 235.2]
|
Diagnostic
|
Prostate Cancer Vs No Prostate Cancer
|
p = 0.003
|
Urine
|
24266816
|
1252
|
Insulin Like Growth Factor Binding Protein 3 (IGFBP3)
|
Protein
|
Humans
|
Upregulated in PCa: [Controls: 0.648; Localised PCa: 0.8862]
|
Diagnostic
|
Prostate Cancer Vs No Prostate Cancer
|
p = 0.003
|
Urine
|
24266816
|
1253
|
Osteopontin (OPN)
|
Protein
|
Humans
|
Upregulated in PCa: [Localised PCa: 613.6; Metastaic PCa: 1024]
|
Prognostic
|
Localised Vs Metastatic Prostate Cancer
|
p = 0.003
|
Urine
|
24266816
|
1272
|
Integrin α3 [ITGA3]
|
Protein
|
Humans
|
Upregulated in Metastatic Prostate Cancer
|
Diagnostic
|
Metastasis Vs Prostate Cancer and BPH
|
p<0.005
|
Urine
|
24371517
|
1273
|
Integrin β1 [ITGB1]
|
Protein
|
Humans
|
Upregulated in Metastatic Prostate Cancer
|
Diagnostic
|
Metastasis Vs Prostate Cancer and BPH
|
p<0.01
|
Urine
|
24371517
|
1327
|
Human Serum Albumin Complexed with Myristate and Aspirin; Apolipoprotein-D; Prostaglandin H2 D-isomerase; Ig A1 Bur; G-protein coupled receptor 115; Cadherin-1; α-N-acetylglucosaminidase; Pro-epidermal growth factor; Apolipoprotein-J precursor; Human Beta-Defensin-1; Matrilin-4; CD14 antigen; Chemo- kine-like factor superfamily-5 isoform a; Fibronectin precursor; Immunoglobulin-kappa light chain varia- ble region; SLURP1.
|
Protein
|
Humans
|
Differentially Expressed
|
Diagnostic
|
Prostate Cancer Vs Benign Prostatic Hyperplasia
|
NA
|
Urine
|
24494028
|
1328
|
Cadherin -1
|
Protein
|
Humans
|
Differentially Expressed
|
Diagnostic
|
Prostate Cancer Vs Benign Prostatic Hyperplasia
|
NA
|
Urine
|
24494028
|
1329
|
Fibronectin
|
Protein
|
Humans
|
Downregulated in PCa
|
Diagnostic
|
Prostate Cancer Vs Benign Prostatic Hyperplasia
|
NA
|
Urine
|
24494028
|
1330
|
TP53INP2
|
Protein
|
Humans
|
Differentially Expressed
|
Diagnostic
|
Prostate Cancer Vs Benign Prostatic Hyperplasia
|
NA
|
Urine
|
24494028
|
1331
|
UAP1+ PDLIM5+ IMPDH2+ HSPD1+ PCA3+ TMPRSS2+ ERG+ GAPDH+ B2M+age+sPSA level
|
mRNA
|
Humans
|
NA
|
Diagnostic
|
Prostate Cancer Vs Benign Prostatic Hyperplasia
|
NA
|
Urine + Plasma
|
24512523
|
1332
|
UAP1+ PDLIM5+ IMPDH2+ HSPD1+ PCA3+ TMPRSS2+ ERG+ GAPDH+ B2M+age+sPSA level
|
mRNA
|
Humans
|
NA
|
Prognostic
|
Gleason Score <7 Vs Gleason Score ≥ 7
|
NA
|
Urine + Plasma
|
24512523
|
1339
|
miR-1826; miR-1234; miR-1238; miR-191*; miR-484; miR-191; miR-451; miR-486-5p; miR-1913; miR-625*; miR-1825; miR-92a; miR-92b; miR-483-5p; miR-486-3p; miR-563; miR-940;
|
miRNA
|
Humans
|
Downregulated in PCa: miR-1826; miR-1234; miR-1238; miR-191*; miR-484; miR-191; miR-451; miR-486-5p; miR-1913; miR-625*; miR-1825; miR-92a; miR-92b; miR-486-3p; miR-563; miR-940; Upregulated in PCa: miR-483-5p
|
Diagnostic
|
Prostate Cancer Vs Healthy Controls
|
p<0.01
|
Urine
|
24563673
|
1340
|
miR-1825
|
miRNA
|
Humans
|
Downregulated in PCa vs BPH vs Healthy
|
Diagnostic
|
Prostate Cancer Vs Benign Prostatic Hyperplasia
|
p<0.01
|
Urine
|
24563673
|
1341
|
miR-484
|
miRNA
|
Humans
|
Downregulated in PCa vs BPH vs Healthy
|
Diagnostic
|
Prostate Cancer Vs Benign Prostatic Hyperplasia
|
p<0.01
|
Urine
|
24563673
|
1342
|
miR-1825 + miR-484
|
miRNA
|
Humans
|
NA
|
Diagnostic
|
Prostate Cancer Vs Benign Prostatic Hyperplasia
|
p<0.01
|
Urine
|
24563673
|
1343
|
miR-1825 + miR-484 + PSA
|
miRNA
|
Humans
|
NA
|
Diagnostic
|
Prostate Cancer Vs Benign Prostatic Hyperplasia
|
p<0.01
|
Urine
|
24563673
|
1426
|
PCA3
|
mRNA
|
Humans
|
Upregulated in PCa
|
Diagnostic
|
Negative Vs Positive Biopsy for PCa
|
p<0.0001
|
Urine
|
24803095
|
1427
|
PCA3
|
mRNA
|
Humans
|
Upregulated in PCa
|
Diagnostic
|
Controls Vs Positive Biopsy for PCa
|
p <0.0001
|
Urine
|
24803095
|
1538
|
C-Terminal Fragment of PSA
|
Protein
|
Humans
|
Upregulated in PCa (PCa: 117; Non PCa: 36.8)
|
Diagnostic
|
Prostate Cancer Vs No Prostate Cancer
|
p=0.0016
|
Urine
|
25233230
|
1541
|
Anterior gradient 2 Wild Type (AGR2wt)
|
mRNA
|
Humans
|
Upregulated in PCa
|
Diagnostic
|
Prostate Cancer Vs Benign prostatic hyperplasia
|
p<0.001
|
Urine
|
25237833
|
1542
|
Anterior gradient 2 Slice Variant C (AGR2-SV-C)
|
mRNA
|
Humans
|
Upregulated in PCa
|
Diagnostic
|
Prostate Cancer Vs Benign prostatic hyperplasia
|
p≤0.001
|
Urine
|
25237833
|
1543
|
Anterior gradient 2 Slice Variant E (AGR2-SV-E)
|
mRNA
|
Humans
|
Upregulated in PCa
|
Diagnostic
|
Prostate Cancer Vs Benign prostatic hyperplasia
|
p<0.01
|
Urine
|
25237833
|
1544
|
Anterior gradient 2 Slice Variant F (AGR2-SV-F)
|
mRNA
|
Humans
|
Upregulated in PCa
|
Diagnostic
|
Prostate Cancer Vs Benign prostatic hyperplasia
|
p<0.01
|
Urine
|
25237833
|
1545
|
Anterior gradient 2 Slice Variant G (AGR2-SV-G)
|
mRNA
|
Humans
|
Upregulated in PCa
|
Diagnostic
|
Prostate Cancer Vs Benign prostatic hyperplasia
|
p≤0.001
|
Urine
|
25237833
|
1546
|
Anterior gradient 2 Slice Variant H (AGR2-SV-H)
|
mRNA
|
Humans
|
Upregulated in PCa
|
Diagnostic
|
Prostate Cancer Vs Benign prostatic hyperplasia
|
p≤0.001
|
Urine
|
25237833
|
1590
|
AK024556; XLOC_007697; LOC100287482; XLOC_005327; XLOC_008559; XLOC_009911;
|
LncRNA
|
Humans
|
Upregulated in PCa
|
Diagnostic
|
Prostate Cancer Vs Adjacent Normal
|
p<0.05
|
Urine
|
25307116
|
1592
|
miRNA-483-5p
|
miRNA
|
Humans
|
Upregulated in PCa
|
Diagnostic
|
Benign Vs Malignant
|
p=0.013
|
Urine
|
25445383
|
1593
|
miRNA-483-5p+ PSA
|
miRNA
|
Humans
|
Upregulated in PCa
|
Diagnostic
|
Benign Vs Malignant
|
p=0.013
|
Urine
|
25445383
|
1694
|
TTTY15-USP9Y
|
mRNA
|
Humans
|
Upregulated in PCa
|
Diagnostic
|
Positive Vs Negative Biopsy
|
p<0.001
|
Urine
|
26008593
|
1695
|
TTTY15-USP9Y + PSA
|
mRNA
|
Humans
|
Downregulated in Gleason Pattern 4 and 5
|
Diagnostic
|
Positive Vs Negative Biopsy
|
p<0.001
|
Urine
|
26008593
|
1696
|
TTTY15-USP9Y
|
mRNA
|
Humans
|
Downregulated in Gleason Upgrade Patients
|
Diagnostic
|
Positive Vs Negative Biopsy
|
p<0.001
|
Urine
|
26008593
|
1697
|
hsa-miR-518a
|
miRNA
|
Humans
|
Upregulated in PCa
|
Diagnostic
|
Prostate Cancer Vs Benign prostatic hyperplasia
|
p< 0.001
|
Urine
|
26126436
|
1698
|
hsa-miR-3605
|
miRNA
|
Humans
|
Upregulated in PCa
|
Diagnostic
|
Prostate Cancer Vs Benign prostatic hyperplasia
|
p=0.033
|
Urine
|
26126436
|
1699
|
hsa-miR-16
|
miRNA
|
Humans
|
Upregulated in PCa
|
Diagnostic
|
Prostate Cancer Vs Benign prostatic hyperplasia
|
p=0.04
|
Urine
|
26126436
|
1700
|
RUN6-2
|
miRNA
|
Humans
|
Downregulated in PCa (BPH: 4098.6; PCa: 2670.6)
|
Diagnostic
|
Prostate Cancer Vs Benign prostatic hyperplasia
|
p< 0.001
|
Urine
|
26126436
|
1701
|
hsa-miR-615-3p
|
miRNA
|
Humans
|
Downregulated in PCa (BPH: 8842.4; PCa: 2781.7)
|
Diagnostic
|
Prostate Cancer Vs Benign prostatic hyperplasia
|
p< 0.001
|
Urine
|
26126436
|
1702
|
hsv1-miR-H18
|
miRNA
|
Humans
|
Downregulated in PCa (BPH: 1030.7; PCa: 619.2)
|
Diagnostic
|
Prostate Cancer Vs Benign prostatic hyperplasia
|
p< 0.001
|
Urine
|
26126436
|
1703
|
hsv2-miR-H9-5p
|
miRNA
|
Humans
|
Downregulated in PCa (BPH: 1030.7; PCa: 619.2)
|
Diagnostic
|
Prostate Cancer Vs Benign prostatic hyperplasia
|
p< 0.001
|
Urine
|
26126436
|
1704
|
hsv1-miR-H18
|
miRNA
|
Humans
|
Upregulated in PCa
|
Diagnostic
|
Prostate Cancer Vs Benign prostatic hyperplasia
|
Tissue, Urine: p<0.001; Serum: p=0.004
|
Tissue+Urine+Serum
|
26126436
|
1705
|
hsv2-miR-H9-5p
|
miRNA
|
Humans
|
Upregulated in PCa
|
Diagnostic
|
Prostate Cancer Vs Benign prostatic hyperplasia
|
Tissue, Urine: p<0.001; Serum: p=0.002
|
Tissue+Urine+Serum
|
26126436
|
1706
|
hsa-miR-615-3p
|
miRNA
|
Humans
|
Upregulated in PCa
|
Diagnostic
|
Prostate Cancer Vs Benign prostatic hyperplasia
|
Tissue: p<0.001;
|
Tissue+Urine+Serum
|
26126436
|
1707
|
hsa-miR-BARTA-4
|
miRNA
|
Humans
|
Upregulated in PCa (Tissue, Serum, Urine)
|
Diagnostic
|
Prostate Cancer Vs Benign prostatic hyperplasia
|
Tissue: p<0.001;
|
Tissue+Urine+Serum
|
26126436
|
1708
|
hsa-miR-4316
|
miRNA
|
Humans
|
Upregulated in PCa (Tissue, Serum, Urine)
|
Diagnostic
|
Prostate Cancer Vs Benign prostatic hyperplasia
|
Tissue: p<0.001; Urine: p=0.022
|
Tissue+Urine+Serum
|
26126436
|
1709
|
hsv1-miR-H18
|
miRNA
|
Humans
|
Upregulated in PCa (Tissue)
|
Diagnostic
|
Prostate Cancer Vs Benign prostatic hyperplasia
|
p<0.05
|
Tissue+Urine
|
26126436
|
1710
|
hsv2-miR-H9-5p
|
miRNA
|
Humans
|
Upregulated in PCa (Tissue)
|
Diagnostic
|
Prostate Cancer Vs Benign prostatic hyperplasia
|
p<0.05
|
Tissue+Urine
|
26126436
|
1724
|
CRIP3
|
Methylation
|
Humans
|
Upregulated in PCa
|
Prognostic
|
Reclassification (Progression Vs No Progression)
|
p=0.017
|
Urine
|
30777394
|
1725
|
miR-24+miR-30c+ Methylation Status of CRIP3
|
miRNA + DNA (Gene)
|
Humans
|
Increased in shorter BCR-free survival
|
Prognostic
|
Reclassification (Progression Vs No Progression)
|
Univariate: p=0.008; Multivariate: p=0.017
|
Urine
|
30777394
|
1813
|
APC; HOXD3; TGFβ2; GSTP1; KLK10
|
Methylation
|
Humans
|
NA
|
Diagnostic
|
Prostate Cancer Vs Benign
|
p<0.05
|
Urine
|
30470249
|
1814
|
APC
|
Methylation
|
Humans
|
NA
|
Diagnostic
|
Benign Vs High CAPRA Score
|
p<0.01
|
Urine
|
30470249
|
1815
|
HOXD3
|
Methylation
|
Humans
|
NA
|
Diagnostic
|
Benign Vs High CAPRA Score
|
p<0.01
|
Urine
|
30470249
|
1816
|
TGFβ2
|
Methylation
|
Humans
|
Methylated in PCa
|
Diagnostic
|
Benign Vs High CAPRA Score
|
p<0.05
|
Urine
|
30470249
|
1817
|
GSTP1
|
Methylation
|
Humans
|
Methylated in PCa
|
Diagnostic
|
Benign Vs High CAPRA Score
|
p<0.01
|
Urine
|
30470249
|
1818
|
KLK10
|
Methylation
|
Humans
|
Methylated in PCa
|
Diagnostic
|
Benign Vs High CAPRA Score
|
p<0.001
|
Urine
|
30470249
|
1819
|
TBX15
|
Methylation
|
Humans
|
Methylated in PCa
|
Diagnostic
|
Benign Vs High CAPRA Score
|
p<0.05
|
Urine
|
30470249
|
1820
|
HOXD3+GSTP1
|
Methylation
|
Humans
|
Methylated in PCa
|
Diagnostic
|
Benign Vs High CAPRA Score
|
p<0.001
|
Urine
|
30470249
|
1821
|
AMBP; (cDNA FLJ50830, highly similar to AMBP); (unnamed protein product); (Isoform 2 of Calmodulin-regulated spectrin-associated protein 1-like 1 (CAMSAP1L1); cDNA FLJ51445, highlysimilar to AMBP protein; Ribosomal RNA upstream binding transcription factor (Fragment, UBTF); Basementmembrane-specific heparan sulfate proteoglycan coreprotein (HSPG2); Ferritin heavy chain (FTH1); Transthyretin; 13 kDa protein; Unknown (protein for IMAGE:3934797); Putative beta-actin-like protein 3 F7 Factor VII active sitemutant immunoconjugate; C11orf54 Aminoacylase-1 (ACY1); Ferritin Light chain (FTL) Coactosin-like protein (COTL1);
|
Protein
|
Humans
|
Methylated in PCa
|
Diagnostic
|
Prostate Cancer Vs Controls and Benign Prostatic Hyperplasia
|
p<0.05
|
Urine
|
30610587
|
1849
|
miR-30c-5p
|
miRNA
|
Humans
|
Differentially Expressed
|
Diagnostic
|
Prostate Cancer Vs Benign prostatic hyperplasia
|
p<0.05
|
Urine
|
30728149
|
1850
|
miR- 222-3p*+ miR-24-3p+ miR-30c-5p
|
miRNA
|
Humans
|
Differentially Expressed
|
Diagnostic
|
Prostate Cancer Vs Benign prostatic hyperplasia
|
p<0.05
|
Urine
|
30728149
|
1851
|
miR- 222-3p*+ miR-24-3p+ miR-30c-5p+PSA
|
miRNA
|
Humans
|
Differentially Expressed
|
Diagnostic
|
Prostate Cancer Vs Benign prostatic hyperplasia
|
p<0.05
|
Urine
|
30728149
|
1858
|
PDGF-BB (Platelet Derived Growth Factor-BB)
|
Protein
|
Humans
|
Upregulated in Recurrent PCa
|
Diagnostic
|
Prostate Cancer Vs No Prostate Cancer
|
p=0.04
|
Urine
|
30374275
|
1859
|
PDGF-BB/Cr (Platelet Derived Growth Factor-BB/creatinine)
|
Protein
|
Humans
|
Upregulated in Recurrent PCa
|
Diagnostic
|
Prostate Cancer Vs No Prostate Cancer
|
p=0.016
|
Urine
|
30374275
|
1862
|
Promoter methylation of: miR-193b+ miR-34b/c
|
Methylation
|
Humans
|
Upregulated in PCa (Non PCa: 1504.7 Vs PCa: 1657.1)
|
Diagnostic
|
Prostate Cancer Vs Controls
|
p<0.05
|
Urine
|
30373654
|
1863
|
Methlyation Status of APC, GSTP1 RARβ2
|
Methylation
|
Humans
|
Methylated in PCa
|
Diagnostic
|
Prostate Cancer Vs Controls
|
p<0.05
|
Urine
|
30373654
|
1864
|
Methlyation Status of APC, GSTP1 RARβ2
|
Methylation
|
Humans
|
Methylated in PCa
|
Diagnostic
|
Prostate Cancer Vs Controls
|
p<0.05
|
Urine
|
30373654
|
1875
|
KNG1 (Kininogen-1);
|
Protein
|
Humans
|
Methylated in PCa
|
Diagnostic
|
Prostate Cancer Vs Benign Prostatic hyperplasia
|
p<0.05
|
Urine
|
30237853
|
1888
|
4-(3,4-dihydro-2,2,4-trimethyl-2H-1-benzopyran-4-yl)-phenol; Estradiol; Ethyl à-hydroxymyristate trisiloxane; 1-(2,4-Dimethylphenyl)-3-(tetrahydrofuryl-2)propane; 2-amino-Imidazole-5-carboxylic acid; 1,1,3,3,5,5,7,7,9,9-decamethyl-pentasiloxane; 1,1,1,5,5,5-hexamethyl-3,3-bis[(trimethylsilyl)oxy]-Trisiloxane; Phthalic acid, bis(7-methyloctyl) ester; 4-Nitro-4’-chlorodiphenylsulfoxide; 1-Propylpentachlorotriphosphazene; 2,6-di-t-butyl-4-hydroxymethylene-2,3,5,6-detetrahydrocyclohexanone
|
Metabolites
|
Humans
|
Downregulated in PCa [SCOâ€spondin (0.1 fold); Complement component C7 (0.1â€fold); Isoform 2 of Ankyrin repeat and SOCS box protein 18 (0.3â€fold); Gelsolin (0.3â€fold); Serum amyloid P-component (0.4â€fold); Ig heavy chain Vâ€I region V35 (0.5â€fold); Complement C1q subcomponent subunit C (0.5â€fold); Complement component C8 alpha chain (0.6â€fold); Isoform 2 of Filamin A (0.6â€fold); and Inter-alpha-trypsin inhibitor heavy chain H2 (0.7â€fold);]
|
Diagnostic
|
Prostate Cancer Vs No Prostate Cancer
|
p<0.05
|
Urine
|
30853355
|