Biomarker ID | 598 |
PMID | 21364037 |
Year | 2011 |
Biomarker | Engrailed-2 (EN2) |
Biomarker Basis | Concentration Based |
Biomolecule | Protein |
Source | Urine |
Subjects | Humans |
Regulation | Upregulated in PCa |
Odds Ratio/Hazard Ratio/Relative Risk | NA |
Effect on Pathways | Pathways Include:-Dopaminergic Neurogenesis |
Experiment | Prostate Cancer Vs Controls |
Type of Biomarker | Diagnostic |
Cohort | En2 transcripts in the human PC cell lines PC3, DU145, and LNCaP together with a nonmalignant cell line derived from normal prostate fibroblasts, WPMY-1. |
Senstivity | 66% |
Specificity | 88.2% |
AUC | 0.8021 (95% CI: 0.7293– 0.8750) |
Accuracy | NA |
Level Of Significance | p<0.0001 |
Method Used | ELISA |
Clinical | No |
Remarks | 58% sensitivity on validation set |
Clinical Trial Number | NA |
Degree Of Validity | Validated on Independent Patient Dataset |
Technical Name | EN2 |