| Biomarker ID | 598 |
| PMID | 21364037 |
| Year | 2011 |
| Biomarker | Engrailed-2 (EN2) |
| Biomarker Basis | Concentration Based |
| Biomolecule | Protein |
| Source | Urine |
| Subjects | Humans |
| Regulation | Upregulated in PCa |
| Odds Ratio/Hazard Ratio/Relative Risk | NA |
| Effect on Pathways | Pathways Include:-Dopaminergic Neurogenesis |
| Experiment | Prostate Cancer Vs Controls |
| Type of Biomarker | Diagnostic |
| Cohort | En2 transcripts in the human PC cell lines PC3, DU145, and LNCaP together with a nonmalignant cell line derived from normal prostate fibroblasts, WPMY-1. |
| Senstivity | 66% |
| Specificity | 88.2% |
| AUC | 0.8021 (95% CI: 0.7293– 0.8750) |
| Accuracy | NA |
| Level Of Significance | p<0.0001 |
| Method Used | ELISA |
| Clinical | No |
| Remarks | 58% sensitivity on validation set |
| Clinical Trial Number | NA |
| Degree Of Validity | Validated on Independent Patient Dataset |
| Technical Name | EN2 |