| Biomarker ID | 694 |
| PMID | 21788966 |
| Year | 2011 |
| Biomarker | Duplex Model (TRPM8 + MSMB) |
| Biomarker Basis | Expression Based |
| Biomolecule | mRNA |
| Source | Urine |
| Subjects | Humans |
| Regulation | Differentially Expressed |
| Odds Ratio/Hazard Ratio/Relative Risk | OR: [TRPM8: 1.120 (95% CI: 1.036–1.211), P=0.004]; OR: [MSMB: 0.828 (95% CI: 0.707–0.970), P= 0.020] |
| Effect on Pathways | Pathways Include(TRPM8):-Ion channel transport; Development Endothelin-1/EDNRA signaling;CREB Pathway; Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds;TRP channels Pathways Include(MSMB):-Oncostatin M |
| Experiment | Prostate Cancer Vs Non- Prostate Cancer |
| Type of Biomarker | Diagnostic |
| Cohort | Total of 176 people were included in the study. A subset with PSA in range (3–15 ng/ml) were selcted out of which 62 had prostate Cancer and 24 did not have Prostate Cancer. |
| Senstivity | 67.9% |
| Specificity | 61.8% |
| AUC | 0.665 (95% CI: 0.548–0.783) |
| Accuracy | NA |
| Level Of Significance | p=0.01 |
| Method Used | qPCR |
| Clinical | No |
| Remarks | NA |
| Clinical Trial Number | NA |
| Degree Of Validity | Not validated on independent patient dataset |
| Technical Name | TRPM8, MSMB |