| Biomarker ID | 660 |
| PMID | 21600800 |
| Year | 2013 |
| Biomarker | TMPRSS2:ERG |
| Biomarker Basis | Expression Based |
| Biomolecule | mRNA |
| Source | Urine |
| Subjects | Humans |
| Regulation | Differentially Expressed |
| Odds Ratio/Hazard Ratio/Relative Risk | Univariate: OR: 12.02 (95% CI 2.37–77.25) |
| Effect on Pathways | Pathways Include(TMPRSS2):- Androgen receptor regulation of biosynthesis and transcription,Androgen receptor proteolysis and transcription regulation Pathways Include(ERG):-Genes targeted by miRNAs in adipocytes WP1992,VEGFA-VEGFR2 Signaling Pathway WP3888 |
| Experiment | Prostate Cancer Vs No Prostate cancer |
| Type of Biomarker | Diagnostic |
| Cohort | 45 people were taken under consideration such that 15 had prostate cancer and 30 did not. |
| Senstivity | 6700% |
| Specificity | 8700% |
| AUC | 0.77 (95% CI: 0.61–0.90) |
| Accuracy | NA |
| Level Of Significance | p=0.001 |
| Method Used | qRT-PCR |
| Clinical | No |
| Remarks | NA |
| Clinical Trial Number | NA |
| Degree Of Validity | Not validated on independent patient dataset |
| Technical Name | TMPRSS2, ERG |