| Biomarker ID | 1231 |
| PMID | 24167554 |
| Year | 2013 |
| Biomarker | miR-205+ miR-214 |
| Biomarker Basis | Expression Based |
| Biomolecule | miRNA |
| Source | Urine |
| Subjects | Humans |
| Regulation | Downregulated in PCa |
| Odds Ratio/Hazard Ratio/Relative Risk | NA |
| Effect on Pathways | Pathways Include(miR-205):- DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; positive regulation of cellular metabolic process; positive regulation of metabolic process; nervous system development Pathways Include(miR-214):- synapse; Golgi apparatus; cell part morphogenesis; cell projection morphogenesis; neuron projection morphogenesis |
| Experiment | Prostate Cancer Vs Healthy Controls |
| Type of Biomarker | Diagnostic |
| Cohort | 36 PCa patients and 12 age and ethnicity matched healthy donors as a non-cancer control group were analysed |
| Senstivity | 89% |
| Specificity | 80% |
| AUC | NA |
| Accuracy | NA |
| Level Of Significance | p<0.001 |
| Method Used | qRT-PCR |
| Clinical | No |
| Remarks | NA |
| Clinical Trial Number | NA |
| Degree Of Validity | Validated on independent patient dataset |
| Technical Name | miR-205, miR-214 |