| Biomarker ID | 446 |
| PMID | 19489685 |
| Year | 2009 |
| Biomarker | DD3 +PSA |
| Biomarker Basis | Concentration Based (pg/μl) |
| Biomolecule | mRNA |
| Source | Urine |
| Subjects | Humans |
| Regulation | Upregulated |
| Odds Ratio/Hazard Ratio/Relative Risk | NA |
| Effect on Pathways | Pathways include(KLK3):-ID regulation of gene expression,Prostate cancer,Androgen receptor proteolysis and transcription regulation,Androgen receptor signaling, proteolysis, and transcription regulation,Insulin-like growth factor (IGF) activity regulation by insulin-like growth factor binding proteins (IGFBPs) |
| Experiment | Benign prostatic hyperplasia (BPH) Vs prostate cancer (PCa) |
| Type of Biomarker | Diagnostic |
| Cohort | 96 age matched patients, 26 with BPH and 70 with Prostate Cancer were included for the study |
| Senstivity | 80.2% |
| Specificity | 100% |
| AUC | NA |
| Accuracy | 80.2% (57.1–93.6) |
| Level Of Significance | p<0.0001 |
| Method Used | RT-PCR |
| Clinical | No |
| Remarks | NA |
| Clinical Trial Number | NA |
| Degree Of Validity | Not validated on independent patient dataset |
| Technical Name | PCA3, KLK3 |