Biomarker ID | 1175 |
PMID | 23861782 |
Year | 2013 |
Biomarker | PCA3 |
Biomarker Basis | Expression Based |
Biomolecule | mRNA |
Source | Urine |
Subjects | Humans |
Regulation | Upregulated in PCa |
Odds Ratio/Hazard Ratio/Relative Risk | Base Model + PCA3: OR: [1.02 (95% CI: 1.01 to 1.02)] |
Effect on Pathways | NA |
Experiment | Prostate Cancer Vs No evidence of Maligancy |
Type of Biomarker | Diagnostic |
Cohort | Population of 300, such that 108 had Prostate Cancer and 192 had no evidence of malignancy were considered for the study |
Senstivity | NA |
Specificity | NA |
AUC | 0.73 (95% CI: 0.68 to 0.79) |
Accuracy | NA |
Level Of Significance | p <0.001 |
Method Used | Assays |
Clinical | No |
Remarks | PCA3 score was calculated as: (mRNA PCA3)/(mRNA PSA) X 1000. ; Patients with PSA in range 2-10ng/ml were chosen for this analysis |
Clinical Trial Number | NA |
Degree Of Validity | Not validated on independent patient dataset |
Technical Name | NA |