| Biomarker ID | 704 |
| PMID | 21822036 |
| Year | 2011 |
| Biomarker | Methylation Status of RARB |
| Biomarker Basis | Methylation Based |
| Biomolecule | Methylation |
| Source | Urine |
| Subjects | Humans |
| Regulation | Hypermethylated in Gleason Score 7 (PMR>=50) |
| Odds Ratio/Hazard Ratio/Relative Risk | OR, 40.0; (95% CI, 2.0–794.9) |
| Effect on Pathways | Pathways Include:-Non-small cell lung cancer,Vitamin A and carotenoid metabolism,Nuclear receptor transcription pathway,Nuclear receptors,Small cell lung cancer |
| Experiment | Gleason Score 6 Vs Gleason Score 7 |
| Type of Biomarker | Prognostic |
| Cohort | 34 patients with untreated prostate cacner were selected, The cases were diagnosed with early- (pT2, n=21) or medium-stage (pT3, n=13) prostate carcinoma of score 6 (n=24) or 7 (n=10). From this cohort, 32 cases were available |
| Senstivity | NA |
| Specificity | NA |
| AUC | NA |
| Accuracy | 44% |
| Level Of Significance | p=0.01 |
| Method Used | Real-time methylation-specific PCR |
| Clinical | No |
| Remarks | NA |
| Clinical Trial Number | NA |
| Degree Of Validity | Not validated on independent patient dataset |
| Technical Name | RARB |