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Biomarker Card

This biomarker card gives comprehensive information about each biomarker.
Detailed Information
Biomarker ID693
PMID21788966
Year2011
BiomarkerTriplex Model (TRPM8 + MSMB+AMACR)
Biomarker BasisExpression Based
BiomoleculemRNA
SourceUrine
SubjectsHumans
RegulationDifferentially Expressed
Odds Ratio/Hazard Ratio/Relative RiskOR: [TRPM8: 1.130 (95% CI: 1.040–1.229), P=0.004]; OR: [MSMB: 0.761 (95% CI: 0.620–0.933), P= 0.009]
Effect on PathwaysPathways include (AMACR):- Primary bile acid biosynthesis, Bile acids and bile salt biosynthesis, Peroxisomal lipid metabolism, Bile acid and bile salt biosynthesis via 7-alpha-hydroxycholesterol, Bile acid and bile salt metabolism Pathways Include(TRPM8):-Ion channel transport; Development Endothelin-1/EDNRA signaling;CREB Pathway; Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds;TRP channels Pathways Include(MSMB):-Oncostatin M
ExperimentProstate Cancer Vs Non- Prostate Cancer
Type of BiomarkerDiagnostic
CohortTotal of 176 people were included in the study. A subset with PSA in range (3–15 ng/ml) were selcted out of which 62 had prostate Cancer and 24 did not have Prostate Cancer.
Senstivity77.4%
Specificity61.8%
AUC0.726 (95% CI: 0.617–0.836)
AccuracyNA
Level Of Significancep<0.001
Method UsedqPCR
ClinicalNo
RemarksNA
Clinical Trial NumberNA
Degree Of ValidityNot validated on independent patient dataset
Technical NameTRPM8, MSMB, AMACR