| Biomarker ID | 544 |
| PMID | 20957673 |
| Year | 2011 |
| Biomarker | TMPRSS2: ERG |
| Biomarker Basis | Expression Based |
| Biomolecule | mRNA |
| Source | Urine |
| Subjects | Humans |
| Regulation | Differentially Expressed |
| Odds Ratio/Hazard Ratio/Relative Risk | Univariate: OR: 1.294 (95% CI:1.100 – 1.522); Multivariate: OR: 1.164 (95% CI: 1.012 – 1.156) |
| Effect on Pathways | Pathways Include(TMPRSS2):- Androgen receptor regulation of biosynthesis and transcription,Androgen receptor proteolysis and transcription regulation Pathways Include(ERG):-Genes targeted by miRNAs in adipocytes WP1992,VEGFA-VEGFR2 Signaling Pathway WP3888 |
| Experiment | Cancer Vs No Malignancy (PSA Range: 4-10) |
| Type of Biomarker | Diagnostic |
| Cohort | 86 untreated patients with CaP and 45 patients with no evidence of malignancy |
| Senstivity | NA |
| Specificity | NA |
| AUC | 0.720 (95% CI: 0.616 -0.823) |
| Accuracy | NA |
| Level Of Significance | Univariate: p=0.002; Multivariate: p=0.028 |
| Method Used | Quantitative PCR |
| Clinical | No |
| Remarks | NA |
| Clinical Trial Number | NA |
| Degree Of Validity | Not validated on independent patient dataset |
| Technical Name | TMPRSS2, ERG |