Biomarker ID | 1332 |
PMID | 24512523 |
Year | 2014 |
Biomarker | UAP1+ PDLIM5+ IMPDH2+ HSPD1+ PCA3+ TMPRSS2+ ERG+ GAPDH+ B2M+age+sPSA level |
Biomarker Basis | Expression Based |
Biomolecule | mRNA |
Source | Urine + Plasma |
Subjects | Humans |
Regulation | NA |
Odds Ratio/Hazard Ratio/Relative Risk | NA |
Effect on Pathways | NA |
Experiment | Gleason Score <7 Vs Gleason Score ≥ 7 |
Type of Biomarker | Prognostic |
Cohort | Training set included 70 patients (35 with biopsy-confirmed PCa and 35 with BPH), and the testing set included 51 patients (26 with biopsy- confirmed PCa and 25 with BPH) . GS ≥ 7 (aggressive PCa; n = 32) from the others (GS < 7 and BPH; n=89). |
Senstivity | 99% |
Specificity | 47% |
AUC | Training = 0.87; Testing = 0.88 |
Accuracy | NA |
Level Of Significance | NA |
Method Used | RT-PCR |
Clinical | No |
Remarks | NA |
Clinical Trial Number | NA |
Degree Of Validity | Validated on independent patient dataset |
Technical Name | NA |