Biomarker ID | 548 |
PMID | 20957673 |
Year | 2011 |
Biomarker | TMPRSS2: ERG |
Biomarker Basis | Expression Based |
Biomolecule | mRNA |
Source | Urine |
Subjects | Humans |
Regulation | Differentially Expressed |
Odds Ratio/Hazard Ratio/Relative Risk | Univariate: OR: 1.220 (95% CI: 1.099 – 1.354); Multivariate: OR: 1.132 (95% CI: 1.010 - 1.268) |
Effect on Pathways | Pathways Include(TMPRSS2):- Androgen receptor regulation of biosynthesis and transcription,Androgen receptor proteolysis and transcription regulation Pathways Include(ERG):-Genes targeted by miRNAs in adipocytes WP1992,VEGFA-VEGFR2 Signaling Pathway WP3888 |
Experiment | Cancer Vs No Malignancy |
Type of Biomarker | Diagnostic |
Cohort | 86 untreated patients with CaP and 45 patients with no evidence of malignancy |
Senstivity | NA |
Specificity | NA |
AUC | 0.732 (95% CI: 0.642-0.822) |
Accuracy | NA |
Level Of Significance | Univariate: p=0.002; Multivariate: p=0.028 |
Method Used | Quantitative PCR |
Clinical | No |
Remarks | NA |
Clinical Trial Number | NA |
Degree Of Validity | Not validated on independent patient dataset |
Technical Name | TMPRSS2, ERG |