Biomarker ID | 1863 |
PMID | 30373654 |
Year | 2018 |
Biomarker | Methlyation Status of APC, GSTP1 RARβ2 |
Biomarker Basis | Methylation Based |
Biomolecule | Methylation |
Source | Urine |
Subjects | Humans |
Regulation | Methylated in PCa |
Odds Ratio/Hazard Ratio/Relative Risk | NA |
Effect on Pathways | Pathways include (GSTP1): Pathways include: Biological oxidations, Metapathway biotransformation, Pathways in cancer, T cell receptor regulation of apoptosis, Metabolism Pathways include (APC): Pathways in cancer, Signal transduction, Irinotecan pathway, Actin cytoskeleton regulation, Apoptosis |
Experiment | Prostate Cancer Vs Controls |
Type of Biomarker | Diagnostic |
Cohort | 32 normal controls along with 87 Prostate cancer samples were selected for analysis |
Senstivity | 94.3% |
Specificity | 84.4% |
AUC | 0.9677 |
Accuracy | 91.6% |
Level Of Significance | p<0.05 |
Method Used | KAPA SYBR FAST qPCR Kit |
Clinical | No |
Remarks | All Genes except GSTP1 showed significant methylation, between cancerous and controls |
Clinical Trial Number | NA |
Degree Of Validity | Validated on independent patient dataset |
Technical Name | NA |