| Biomarker ID | 510 |
| PMID | 20043080 |
| Year | 2010 |
| Biomarker | TRPM8 (transient receptor potential member 8) |
| Biomarker Basis | Expression Based |
| Biomolecule | mRNA |
| Source | Urine |
| Subjects | Humans |
| Regulation | Upregulated in Metastatis |
| Odds Ratio/Hazard Ratio/Relative Risk | NA |
| Effect on Pathways | Pathways Include:- Ion channel transport; Development Endothelin-1/EDNRA signaling;CREB Pathway; Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds;TRP channels |
| Experiment | Healthy Vs Metastatic |
| Type of Biomarker | Diagnostic |
| Cohort | 18 healthy men, 10 with localised Prostate cancer and 18 with Metastatic Cancer were taken for the study. No significant difference between healthy men and localised PCA was found |
| Senstivity | NA |
| Specificity | NA |
| AUC | NA |
| Accuracy | NA |
| Level Of Significance | p<0.0001 |
| Method Used | RT-PCR |
| Clinical | No |
| Remarks | GAPDH-normalized TRPM8 levels (TRPM8/GAPDH) were used for analysis |
| Clinical Trial Number | NA |
| Degree Of Validity | Not validated on independent patient dataset |
| Technical Name | TRPM8 |