Biomarker ID | 510 |
PMID | 20043080 |
Year | 2010 |
Biomarker | TRPM8 (transient receptor potential member 8) |
Biomarker Basis | Expression Based |
Biomolecule | mRNA |
Source | Urine |
Subjects | Humans |
Regulation | Upregulated in Metastatis |
Odds Ratio/Hazard Ratio/Relative Risk | NA |
Effect on Pathways | Pathways Include:- Ion channel transport; Development Endothelin-1/EDNRA signaling;CREB Pathway; Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds;TRP channels |
Experiment | Healthy Vs Metastatic |
Type of Biomarker | Diagnostic |
Cohort | 18 healthy men, 10 with localised Prostate cancer and 18 with Metastatic Cancer were taken for the study. No significant difference between healthy men and localised PCA was found |
Senstivity | NA |
Specificity | NA |
AUC | NA |
Accuracy | NA |
Level Of Significance | p<0.0001 |
Method Used | RT-PCR |
Clinical | No |
Remarks | GAPDH-normalized TRPM8 levels (TRPM8/GAPDH) were used for analysis |
Clinical Trial Number | NA |
Degree Of Validity | Not validated on independent patient dataset |
Technical Name | TRPM8 |