| Biomarker ID | 246 |
| PMID | 18245462 |
| Year | 2008 |
| Biomarker | SPINK1, PCA3, GOLPH2, TMPRSS2:ERG |
| Biomarker Basis | Expression Based |
| Biomolecule | mRNA |
| Source | Urine |
| Subjects | Humans |
| Regulation | Upregulated in PCa |
| Odds Ratio/Hazard Ratio/Relative Risk | NA |
| Effect on Pathways | Pathways Include:-Proteins Involved in Prostate Cancer |
| Experiment | Normal Vs Cancer |
| Type of Biomarker | Diagnostic |
| Cohort | Total of 234 samples were taken. 138 having prostate cancer (86 positive needle biopsy and 52 radical prostatectomy) and 96 negative biopsy patients. |
| Senstivity | 6590% |
| Specificity | 7600% |
| AUC | 0.758 |
| Accuracy | NA |
| Level Of Significance | p=1.91E-11 |
| Method Used | qPCR |
| Clinical | No |
| Remarks | For the multivariate analysis, AIC-based backward selection was used to drop insignificant terms. |
| Clinical Trial Number | NA |
| Degree Of Validity | Not validated on independent patient dataset |
| Technical Name | SPINK1, PCA3, GOLM1, TMPRSS2, ERG |