Biomarker ID | 247 |
PMID | 18245462 |
Year | 2008 |
Biomarker | SPINK1, PCA3, GOLPH2, TMPRSS2:ERG |
Biomarker Basis | Expression Based |
Biomolecule | mRNA |
Source | Urine |
Subjects | Humans |
Regulation | Upregulated in PCa |
Odds Ratio/Hazard Ratio/Relative Risk | NA |
Effect on Pathways | Pathways Include:-Proteins Involved in Prostate Cancer |
Experiment | Normal Vs Cancer |
Type of Biomarker | Diagnostic |
Cohort | Total of 234 samples were taken. 138 having prostate cancer (86 positive needle biopsy and 52 radical prostatectomy) and 96 negative biopsy patients. |
Senstivity | 6230% |
Specificity | 7500% |
AUC | 0.736 |
Accuracy | NA |
Level Of Significance | p=1.91E-11 |
Method Used | qPCR |
Clinical | No |
Remarks | For the multivariate analysis, AIC-based backward selection was used to drop insignificant terms. Results shown for using LOOCV (Leave one out Cross Validation) |
Clinical Trial Number | NA |
Degree Of Validity | Not validated on independent patient dataset |
Technical Name | SPINK1, PCA3, GOLM1, TMPRSS2, ERG |