Biomarker Card
This biomarker card gives comprehensive information about each biomarker.
| Detailed Information | |
|---|---|
| Biomarker ID | 661 |
| PMID | 21600800 |
| Year | 2013 |
| Biomarker | PSA +PCA3 + TMPRSS2:ERG |
| Biomarker Basis | Expression Based |
| Biomolecule | mRNA |
| Source | Urine |
| Subjects | Humans |
| Regulation | Differentially Expressed |
| Odds Ratio/Hazard Ratio/Relative Risk | NA |
| Effect on Pathways | Pathways Include (KLK3) :-ID regulation of gene expression,Prostate cancer, Androgen receptor proteolysis and transcription regulation, Androgen receptor signaling, proteolysis, and transcription regulation, Insulin-like growth factor (IGF) activity regulation by insulin-like growth factor binding proteins (IGFBPs) Pathways Include(TMPRSS2):- Androgen receptor regulation of biosynthesis and transcription,Androgen receptor proteolysis and transcription regulation |
| Experiment | Prostate Cancer Vs No Prostate cancer |
| Type of Biomarker | Diagnostic |
| Cohort | 45 people were taken under consideration such that 15 had prostate cancer and 30 did not. |
| Senstivity | 80% |
| Specificity | 90% |
| AUC | 0.88 |
| Accuracy | NA |
| Level Of Significance | NA |
| Method Used | qRT-PCR |
| Clinical | No |
| Remarks | NA |
| Clinical Trial Number | NA |
| Degree Of Validity | Not validated on independent patient dataset |
| Technical Name | KLK3, PCA3, TMPRSS2 |