Biomarker ID | 690 |
PMID | 21788966 |
Year | 2011 |
Biomarker | AMACR |
Biomarker Basis | Expression Based |
Biomolecule | mRNA |
Source | Urine |
Subjects | Humans |
Regulation | Differentially Expressed |
Odds Ratio/Hazard Ratio/Relative Risk | OR: 1.048 (95% CI: 0.922-1.191) |
Effect on Pathways | Pathways include:- Primary bile acid biosynthesis, Bile acids and bile salt biosynthesis, Peroxisomal lipid metabolism, Bile acid and bile salt biosynthesis via 7-alpha-hydroxycholesterol, Bile acid and bile salt metabolism |
Experiment | Prostate Cancer Vs Non- Prostate Cancer |
Type of Biomarker | Diagnostic |
Cohort | Total of 176 people were included in the study. A subset with PSA in range (3–15 ng/ml) were selcted out of which 62 had prostate Cancer and 24 did not have Prostate Cancer. |
Senstivity | 63.2% |
Specificity | 64.9% |
AUC | 0.626 (95% CI: 0.511–0.741) |
Accuracy | NA |
Level Of Significance | p=0.04 |
Method Used | qPCR |
Clinical | No |
Remarks | NA |
Clinical Trial Number | NA |
Degree Of Validity | Not validated on independent patient dataset |
Technical Name | AMACR |