The total number of records retrieved from this search are 100. Click on ID to see further detail.

ID	Virus name	Virus strain	Virus genome type	Virus family	Virus genome modification	Virus alone	Virus in combination with drug/radiation	Immune gene insertion in viral genome	Source of cell line	Origin of cell line	Cell line	Concentration of cell line	In-vitro toxicity	Assay	In-vitro virus concentration	In-vitro result	Model organism	In-vivo virus concentration	In-vivo toxicity	In-vivo result	Mode of delivery	Pathway induced	Immunogenic effect	Clinical trial	PMID
OV_37	Adenovirus	oAd/DCN/LRP	DNA	Adenoviridae	Insertional mutant for DCN and LRP gene	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	BALB/c nude mice xenograft for MIA PaCa-2 cell line 5.0E+6 cells	2.0E+10 VP (on 0, 2, and 4 days)	Slight hepatotoxicity	Reduction in tumor volume to 230 cubic millimeter compared to control 300 cubic millimeter after 46 days	Intravenously	Inhibits Wnt/β-catenin and TGF-β1 signaling pathways	IL-6 production increased by 3 folds as compared to normal	NA	26471393
OV_38	Adenovirus	oAd/DCN/LRP-PEG	DNA	Adenoviridae	Insertional mutant for DCN and LRP gene with polyethylene glycol	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	BALB/c nude mice xenograft for MIA PaCa-2 cell line 5.0E+4 cells	2.0E+10 VP (on 0, 2, and 4 days)	NA	Reduction in tumor volume to 198 cubic millimeter compared to control 300 cubic millimeter after 46 days	Intravenously	Inhibits Wnt/β-catenin and TGF-β1 signaling pathways	NA	NA	26471393
OV_39	Adenovirus	oAd/DCN/LRP-PEG-NT	DNA	Adenoviridae	Insertional mutant for DCN and LRP gene with NT-conjugated polyethylene glycol	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	BALB/c nude mice xenograft for MIA PaCa-2 cell line 5.0E+4 cells	2.0E+10 VP (on 0, 2, and 4 days)	NA	Reduction in tumor volume to 100 cubic millimeter compared to control 300 cubic millimeter after 46 days	Intravenously	Inhibits Wnt/β-catenin and TGF-β1 signaling pathways	NA	NA	26471393
OV_357	Adenovirus	Adhz60	DNA	Adenoviridae	E1b-deleted mutant	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Athymic BALB/c nu/nu male mice (subcutaneously injected A549 lung cancer cells, 5.0E+6 cells)	1.0E+9 pfu (every 3 days for at total 4 treatments)	NA	41% smaller tumor size compared to the negative control virus AdLacZ	Intratumorally	NA	NA	NA	26561948
OV_358	Adenovirus	Adhz60	DNA	Adenoviridae	E1b-deleted mutant	No	Virus in combination with temozolomide (TMZ) intraperitoneally at 50 mg/Kg for five consecutive days	No	NA	NA	NA	NA	NA	NA	NA	NA	Athymic BALB/c nu/nu male mice (subcutaneously injected A549 lung cancer cells, 5.0E+6 cells)	1.0E+9 pfu (every 3 days for at total 4 treatments)	NA	70% smaller tumor size compared to the negative control virus AdLacZ	Intratumorally	JNK activation induces autophagy	NA	NA	26561948
OV_359	Adenovirus	AdLacZ	DNA	Adenoviridae	E1/E3-deleted mutant	No	Virus in combination with temozolomide (TMZ) intraperitoneally at 50 mg/Kg for five consecutive days	No	NA	NA	NA	NA	NA	NA	NA	NA	Athymic BALB/c nu/nu male mice (subcutaneously injected A549 lung cancer cells, 5.0E+6 cells)	1.0E+9 pfu (every 3 days for at total 4 treatments)	NA	30% smaller tumor size compared to the negative control virus AdLacZ	Intratumorally	JNK activation induces autophagy	NA	NA	26561948
OV_401	Herpes simplex virus	ICP10PK	DNA	Herpesviridae	Deletion mutant with R1 domain poorly functional in HSV-1	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Xenograft male BALB/c nu/nu mice (subcutaneously injected with 1.0E+7 A3755 cells in 100 μl)	100 μl; 1.0E+6 PFU on day 7	NA	On day 29 , tumor growth ratio reached 2 as compared to 13 (tumour growth ratio - dividing each tumour volume measured over time by the initial tumour volume on day 7)	Intratumorally	NA	MICA and TNF-alpha expressions are upregulated	NA	26602205
OV_566	Adenovirus	OBP-301 (telomelysin)	DNA	Adenoviridae	Viral mutant with human telomerase reverse transcriptase (hTERT) promotor for selective replication in cancer cells	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Female BALB/c nu/nu mice inoculated subcutaneously with MNNG/HOS-Luc cells (5.0E+6 cells per site)	5.0E+7 PFU	NA	Proliferating tumor cells expressing ki67 get reduced from 550 cells to 250 cells	Direct injection	NA	NA	NA	27356624
OV_567	Adenovirus	OBP-301 (telomelysin)	DNA	Adenoviridae	Viral mutant with human telomerase reverse transcriptase (hTERT) promotor for selective replication in cancer cells	No	Viral strain in combination with cisplatin (CDDP, 4 mg/kg body weight ) and doxorubicin (DOX, 2 mg/kg body weight )[drugs were given intraperitoneally]	No	NA	NA	NA	NA	NA	NA	NA	NA	Female BALB/c nu/nu mice inoculated subcutaneously with MNNG/HOS-Luc cells (5.0E+6 cells per site)	5.0E+7 PFU	NA	Proliferating tumor cells expressing ki67 get reduced from 550 cells to 75 cells	Direct injection	NA	NA	NA	27356624
OV_602	Alphavirus	M1	RNA	Togaviridae	None	No	Viral strain in combination with H89 (10 mg/kg/d), injected intraperitoneally	No	NA	NA	NA	NA	NA	NA	NA	NA	Female BALB/c-nu/nu mice inoculated subcutaneously with HCT-116, 5.0E+6 cells per mouse	3.0E+7 PFU/d	NA	Reduction in tumor volume to 0.2 cubic centimeter compared to control 1cubic centimeter after 27 days	intravenously	Activates Caspase-3	NA	NA	27374176
OV_603	Alphavirus	M1	RNA	Togaviridae	None	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Female BALB/c-nu/nu mice inoculated subcutaneously with HCT-116, 5.0E+6 cells per mouse	3.0E+7 PFU/d	NA	Reduction in tumor volume to 0.76 cubic centimeter compared to control 1cubic centimeter after 27 days	intravenously	Activates Caspase-3 (very small)	NA	NA	27374176
OV_604	Alphavirus	M1	RNA	Togaviridae	None	No	Viral strain in combination with H89 (10 mg/kg/d), injected intraperitoneally	No	NA	NA	NA	NA	NA	NA	NA	NA	Female BALB/c-nu/nu mice inoculated subcutaneously with Capan-1, 3.0E+6 cells per mouse	3.0E+7 PFU/d	NA	Reduction in tumor volume to 0.1 cubic centimeter compared to control 1cubic centimeter after 23 days	intravenously	Activates Caspase-3	NA	NA	27374176
OV_605	Alphavirus	M1	RNA	Togaviridae	None	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Female BALB/c-nu/nu mice inoculated subcutaneously with Capan-1, 3.0E+6 cells per mouse	3.0E+7 PFU/d	NA	Reduction in tumor volume to 0.2 cubic centimeter compared to control 1cubic centimeter after 23 days	intravenously	Activates Caspase-3 (very small)	NA	NA	27374176
OV_749	Adenovirus	AdAFPp-E1A	DNA	Adenoviridae	The viral mutant with E1A gene driven by AFP promoter	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	HepG2 orthotopic liver xenograft tumor in Balb/c athymic nude	NA	NA	Reduction in tumor weight to 0.2 g compared to control 0.75 g after 18 days	intravenously	NA	NA	NA	27450327
OV_750	Adenovirus	AdAFPp-E1A-122	DNA	Adenoviridae	The viral insertion mutant with miR-122 target sequence into AdAFPp-E1A for negatively regulating E1A gene expression	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	HepG2 orthotopic liver xenograft tumor in Balb/c athymic nude	NA	NA	Reduction in tumor weight to 0.2 g compared to control 0.75 g after 18 days	intravenously	NA	NA	NA	27450327
OV_751	Adenovirus	AdTrack	DNA	Adenoviridae	None	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	HepG2 orthotopic liver xenograft tumor in Balb/c athymic nude	NA	NA	Reduction in tumor weight to 0.85 g compared to control 0.75 g after 18 days	intravenously	NA	NA	NA	27450327
OV_752	Adenovirus	AdAFPp-E1A-122	DNA	Adenoviridae	The viral insertion mutant with miR-122 target sequence into AdAFPp-E1A for negatively regulating E1A gene expression	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	HepG2 subcutaneous liver xenograft tumor in Balb/c athymic nude	NA	NA	Reduction in tumor volume to 0.8 cubic centimeter compared to control 2.4 cubic centimeter after 15 days	intravenously	NA	NA	NA	27450327
OV_829	Adenovirus	SG611-VSTM1	DNA	Adenoviridae	A VSTM1 gene expression cassette containing VSTM1 cDNA, cytomegalovirus promoter and SV40 polyA was inserted into the genome of SG611 to generate SG611-VSTM1	No	Viral strain in combination with DNR 300 μg/kg	No	NA	NA	NA	NA	NA	NA	NA	NA	Xenograft BALB/c nu/nu female mice subcutaneously injected with 1.0E+7 × 10⁷ K562 cells in a total volume of 100 μl	1.0E+9 pfu/ml	NA	Reduction in tumor volume to 20 cubic millimeter compared to control 880 cubic millimeter after 30 days	Intratumoral	Enhanced apoptosis activation is observed	NA	NA	27472927
OV_830	Adenovirus	SG611-VSTM1	DNA	Adenoviridae	A VSTM1 gene expression cassette containing VSTM1 cDNA, cytomegalovirus promoter and SV40 polyA was inserted into the genome of SG611 to generate SG611-VSTM1	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Xenograft BALB/c nu/nu female mice subcutaneously injected with 1.0E+7 × 10⁷ K562 cells in a total volume of 100 μl	1.0E+9 pfu/ml	NA	Reduction in tumor volume to 80 cubic millimeter compared to control 880 cubic millimeter after 30 days	Intratumoral	Enhanced apoptosis activation is observed	NA	NA	27472927
OV_831	Adenovirus	SG611	DNA	Adenoviridae	None	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Xenograft BALB/c nu/nu female mice subcutaneously injected with 1.0E+7 × 10⁷ K562 cells in a total volume of 100 μl	1.0E+9 pfu/ml	NA	Reduction in tumor volume to 120 cubic millimeter compared to control 880 cubic millimeter after 30 days	Intratumoral	Enhanced apoptosis activation is observed	NA	NA	27472927
OV_884	Herpes simplex virus	JS1	DNA	Herpesviridae	JS1 strain mutant in ICP34.5 and ICP47	Yes	No	No	ATCC	NA	NA	NA	NA	MTT assay	NA	NA	BALB/c nude mice xenograft for HT-29 cell	1.0E+8 pfu	NA	Compelte reduction of tumor after 28 days	intraperitonial	NA	Increase production of IFN-gamma	NA	12595888
OV_916	Herpes simplex virus	Baco-1	DNA	Herpesviridae	Non- fusogenic ligated with EGFP protein	Yes	No	No	ATCC	NA	NA	NA	NA	NA	NA	NA	BALB/cByJIcrSmnHsd-scid mice orthotopic xenograft for prostate cancer cell line	2.0E+7 pfu	NA	30% reduction in tumor volume	Tail vein injection of virus	NA	NA	NA	15129429
OV_917	Herpes simplex virus	Synco-2	DNA	Herpesviridae	Fusogenic membrane ligated with GALV.fus protein	Yes	No	No	ATCC	NA	NA	NA	NA	NA	NA	NA	BALB/cByJIcrSmnHsd-scid mice orthotopic xenograft for prostate cancer cell line	2.0E+7 pfu	NA	50% reduction in tumor volume	Tail vein injection of virus	NA	NA	NA	15129429
OV_918	Herpes simplex virus	Synco-2D	DNA	Herpesviridae	Double fusogenic expressing EGFP and GALV.fus protein	Yes	No	No	ATCC	NA	NA	NA	NA	NA	NA	NA	BALB/cByJIcrSmnHsd-scid mice orthotopic xenograft for prostate cancer cell line	2.0E+7 pfu	NA	60% reduction in tumor volume	Tail vein injection of virus	NA	NA	NA	15129429
OV_919	Herpes simplex virus	Baco-1	DNA	Herpesviridae	Non- fusogenic ligated with EGFP protein	Yes	No	No	ATCC	NA	NA	NA	NA	NA	NA	NA	BALB/cByJIcrSmnHsd-scid mice metastatic lung metastatic model	2.0E+7 pfu	NA	Lung metastasis were not detected after 40 days when stained with bouins fixative	Tail vein injection of virus	NA	NA	NA	15129429
OV_920	Herpes simplex virus	Synco-2	DNA	Herpesviridae	Fusogenic membrane ligated with GALV.fus protein	Yes	No	No	ATCC	NA	NA	NA	NA	NA	NA	NA	BALB/cByJIcrSmnHsd-scid mice metastatic lung metastatic model	2.0E+7 pfu	NA	Lung metastasis were not detected after 40 days when stained with bouins fixative	Tail vein injection of virus	NA	NA	NA	15129429
OV_921	Herpes simplex virus	Synco-2D	DNA	Herpesviridae	Double fusogenic expressing EGFP and GALV.fus protein	Yes	No	No	ATCC	NA	NA	NA	NA	NA	NA	NA	BALB/cByJIcrSmnHsd-scid mice metastatic lung metastatic model	2.0E+7 pfu	NA	Lung metastasis were not detected after 40 days when stained with bouins fixative	Tail vein injection of virus	NA	NA	NA	15129429
OV_922	Adenovirus	CNHK-300	DNA	Adenoviridae	Addition of 3 hTERT promoter in E boxes of genome	Yes	No	No	Synthesized	NA	NA	NA	NA	NA	NA	NA	BALB/c nude mice	1.0E+9 pfu	NA	Tumor volume decreases to 600 mm3 after 20 days as compared to control	Tail vein injection of virus	NA	NA	NA	15243805
OV_923	Adenovirus	ONYX-015	DNA	Adenoviridae	None	Yes	No	No	Onyx pharmaceutical	NA	NA	NA	NA	NA	NA	NA	BALB/c nude mice	1.0E+9 pfu	NA	Tumor volume decreases to 200 mm3 after 20 days as compared to control	Tail vein injection of virus	NA	NA	NA	15243805
OV_924	Adenovirus	CNHK-300	DNA	Adenoviridae	Addition of 3 hTERT promoter in E boxes of genome	Yes	No	No	Synthesized	NA	NA	NA	NA	NA	NA	NA	BALB/c nude mice	1.0E+9 pfu	NA	Tumor volume decreases to 200 mm3 after 20 days as compared to control	Tail vein injection of virus	NA	NA	NA	15243805
OV_925	Adenovirus	CNHK-300	DNA	Adenoviridae	Addition of 3 hTERT promoter in E boxes of genome	Yes	No	No	Synthesized	NA	NA	NA	NA	NA	NA	NA	BALB/c nude mice	5.0E+8 pfu	NA	Tumor volume decreases to 500 mm3 after 20 days as compared to control	Tail vein injection of virus	NA	NA	NA	15243805
OV_926	Adenovirus	CNHK-300	DNA	Adenoviridae	Addition of 3 hTERT promoter in E boxes of genome	Yes	No	No	Synthesized	NA	NA	NA	NA	NA	NA	NA	BALB/c nude mice	1.0E+9 pfu	NA	Tumor volume decreases to 400 mm3 after 20 days as compared to control	Tail vein injection of virus	NA	NA	NA	15243805
OV_1103	Adenovirus	ZD55-IL-24	DNA	Adenoviridae	Adenovirus expressing ZD55 gene and IL-24 gene	Yes	No	Expressing IL-24 gene	Shanghai cell collection	NA	NA	NA	NA	NA	NA	NA	Athymic BALB/c nude mice xenograft for SW620 cell line	5.0E+8 cells per well	NA	Decrease in tumor volume below 800mm³ as compared to control	Intratumoral injection	Apoptosis induction and cspase 3 activation	NA	NA	15661558
OV_1104	Adenovirus	Ad-IL-24	DNA	Adenoviridae	Adenovirus expressing IL-24 gene	Yes	No	Expressing IL-24 gene	Shanghai cell collection	NA	NA	NA	NA	NA	NA	NA	Athymic BALB/c nude mice xenograft for SW620 cell line	5.0E+8 cells per well	NA	Decrease in tumor volume below 600mm³ as compared to control	Intratumoral injection	Apoptosis induction and cspase 3 activation	NA	NA	15661558
OV_1105	Adenovirus	ONYX-015	DNA	Adenoviridae	None	Yes	No	No	Shanghai cell collection	NA	NA	NA	NA	NA	NA	NA	Athymic BALB/c nude mice xenograft for SW620 cell line	5.0E+8 cells per well	NA	Complete reduction in tumor volume	Intratumoral injection	Apoptosis induction and cspase 3 activation	NA	NA	15661558
OV_1136	Sindbis virus	AR339	RNA	Togaviridae	None	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	BALB/c nude mice xenograft for HeLaS3 cell line	1.0E+6 pfu	NA	Complete reduction in tumor volume after 30 days	Intratumoral injection	Apoptosis induction in cancer cell lines	NA		15958641
OV_1137	Sindbis virus	AR339	RNA	Togaviridae	None	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	BALB/c nude mice xenograft for C33A cell line	1.0E+6 pfu	NA	Complete reduction in tumor volume after 30 days	Intratumoral injection	Apoptosis induction in cancer cell lines	NA		15958641
OV_1138	Sindbis virus	AR339	RNA	Togaviridae	None	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	BALB/c nude mice xenograft for C33A cell line	1.0E+6 pfu	NA	Rediction in tumor volume to 200mm after 50 days	Intravenous injection	Apoptosis induction in cancer cell lines	NA		15958641
OV_1146	Herpes simplex virus	Mutant	DNA	Herpesviridae	Mutant for gamma 34.5, lacZ and alpha 47 gene	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	BALB/c nude mice xenograft for Human prostatic cancer HONDA	2.0E+6 pfu	NA	Total reduction in tumor volume in 2 mice after 3 days	Intraneoplastically	NA	NA	NA	16278413
OV_1148	Herpes simplex virus	Mutant	DNA	Herpesviridae	Mutant for gamma 34.5, lacZ and alpha 47 gene	No	Virus strain in combination with flutamide	No	NA	NA	NA	NA	NA	NA	NA	NA	BALB/c nude mice xenograft for Human prostatic cancer HONDA	No	NA	Significant reduction in tumor volume as compared to flutamide alone	Subcutaneous	NA	NA	NA	16278413
OV_1314	Adenovirus	OBP-301	DNA	Adenoviridae	None	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	BALB/c nude mice xenograft for Human prostate cancer cell line LNCaP	1.0E+7 pfu	NA	Reduction in tumor size after day 20, 3 times administration	Intratumoral	NA	NA	NA	18274558
OV_1351	Adenovirus	AdCN101	DNA	Adenoviridae	24bp deletion between E1Ap and E1A	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	BALB/c nude mice, xenograft for BEL7404	2.0E+8 pfu	NA	Significant reduction in tumor volume after 7 weeks and increase in survival	Intratumoral	NA	NA	NA	18281783
OV_1352	Adenovirus	AdCN102	DNA	Adenoviridae	Addition of hTERT promoter ahead of E1A	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	BALB/c nude mice, xenograft for BEL7404	2.0E+8 pfu	NA	Significant reduction in tumor volume after 7 weeks and increase in survival	Intratumoral	NA	NA	NA	18281783
OV_1353	Adenovirus	AdCN103	DNA	Adenoviridae	24 bp deletion in hTERT promoter	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	BALB/c nude mice, xenograft for BEL7404	2.0E+8 pfu	NA	Significant reduction in tumor volume after 7 weeks and increase in survival	Intratumoral	NA	NA	NA	18281783
OV_1384	Adenovirus	ZD55-Ki67	DNA	Adenoviridae	Expressing Ki67 ShRNA	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	BALB/c nude mice xenograft for Human prostate cancer cell line LNCaP	7.0E+8 cells per well	NA	Significant reduction in tumor size after 9 weeks	Intratumoral	Induction of apoptosis	NA	NA	18690204
OV_1442	Adenovirus	ZD-55-IL-18	DNA	Adenoviridae	None	Yes	No	Virus expressing IL-18 gene	NA	NA	NA	NA	NA	NA	NA	NA	BALB/c mice xenograft for A375	7.0E+8 pfu	NA	Reduction in tumor volume after 7 weeks	Intratumoral	Induction of apoptosis, activation of caspase 3	NA	NA	19498459
OV_1727	Measles virus	MV-Edm strain	RNA	Paramyxoviridae	MV-NPL virus , addition of P, N and L gene	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	BALB/c nude mice xenograft for A-498 cells	1.0E+5 pfu	NA	Survival rate increased in 55% of animals	Intratumoral	Virus induce apoptosis in cancer cells	Induce expression of IFN-gamma, an antiviral protein	NA	20051938
OV_1728	Measles virus	MV-Edm strain	RNA	Paramyxoviridae	MV-P virus , addition of P gene	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	BALB/c nude mice xenograft for A-498 cells	1.0E+5 pfu	NA	Survival rate increased in 11% of animals	Intratumoral	Virus induce apoptosis in cancer cells	Induce expression of IFN-gamma, an antiviral protein	NA	20051938
OV_1729	Measles virus	MV-Edm strain	RNA	Paramyxoviridae	MV-Etag virus	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	BALB/c nude mice xenograft for A-498 cells	1.0E+5 pfu	NA	No effect on increase in survival time	Intratumoral	Virus induce apoptosis in cancer cells	Induce expression of IFN-gamma, an antiviral protein	NA	20051938
OV_2093	Adenovirus	Mutant	DNA	Adenoviridae	Deletion of E1BK55KD gene and addition of shMPP1 expressing cassette	Yes	No	Virus expressing IL-24 gene	NA	Human colon cancer cell line	SW620	NA	NA	NA	NA	NA	BALB/c nude mice xenograft for SW620 cell line (5.0E+6 cells)	2.0E+9 pfu	NA	Reduction in tumor volume below 100 mm after 9 weeks	NA	Induction of apoptosis	NA	NA	21794078
OV_2138	Adenovirus	Mutant	DNA	Adenoviridae	Deletion of E1BK55KD gene and addition of TRAIL gene	Yes	No	Virus expressing TRAIL gene	ATCC	Human hepatocellular carcinoma cell line	Huh-7	NA	NA	NA	NA	NA	BALB/c mice xenograft for Huh7 cell line (5.0E+6 × 10⁶ pfu)	2.0E+9 pfu	NA	Significant reduction in tumor volume below 100mm and increase in median survival time after 57 days	Intratumoral	Induction of apoptosis in cancer as measured by TUNEL assay	NA	NA	21979578
OV_2209	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	Hongkong university	Human nasopharyngeal carcinoma cell line	CNE-2	NA	NA	NA	NA	NA	Balb/c nude mice xenograft for CNE-2 cell line (1.0E+6 × 10⁶ cells)	2.0E+7 pfu	NA	Virus treated mice shows complete regression in tumor and exhibit longer survival time	Intratumoral	NA	NA	NA	22059912
OV_2210	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	Hongkong university	Human nasopharyngeal carcinoma cell line	SUNE-1	NA	NA	NA	NA	NA	Balb/c nude mice xenograft for SUNE-1 cell line (5.0E+5 × 10⁵ cells)	2.0E+7 pfu	NA	Virus treated mice shows complete regression in tumor and exhibit longer survival time	Intratumoral	NA	NA	NA	22059912
OV_2211	Newcastle disease virus	wild type	RNA	Paramyxoviridae	None	No	Virus in combination with cisplatin	No	Chinese academy of sciece	Human small cell lung cancer cell line	A549	NA	NA	NA	NA	NA	BALB/c nude mice xenograft for A549 cell line	1.0E+7 pfu	NA	Tumor volume decreased to 500mm after 57 days	Intratumoral	Induction of caspase and apoptotic pathway as detected by Hoechst staining and TUNEL assay	NA	NA	22095029
OV_2252	Herpes simplex virus	HSV-1-G47-delta	DNA	Herpesviridae	Mutant for Gamma34.5, ICP6 and alpha47 gene	Yes	No	No	State key laboratory of oncology China	Human breast cancer cell line	MDA-MB-435	NA	NA	NA	NA	NA	BALB/c nude mice xenograft for MDA-MB-435(1.0E+6 × 10⁶)	2.0E+7 pfu	NA	Tumor volume decreased by 9 fold after 56 days	Intratumoral	Caspase activation	NA	NA	22108767
OV_2553	Adenovirus	AD55-Apoptin	DNA	Adenoviridae	Deletion of E1B gene and insertion of Apoptin gene	Yes	No	No	ATCC	Human hepatocellular carcinoma cell line	Huh-7	NA	NA	NA	NA	NA	BALB/c nude mice xenograft for Huh7 cell line (1.0E+7)	3.0E+8 pfu	NA	Reduction in tumor volume below 425mm after 16 days	Intratumoral	Induction of apotosis as measured by TUNEL assay	NA	NA	22321574
OV_2578	Adenovirus	SG600-IL-24+IFN	DNA	Adenoviridae	Deletion of E1B gene and insertion of IL-24 gene and addition of IN	Yes	No	Virus expressing IL-24 gene and IFN gene	ATCC	Human hepatocellular carcinoma cell line	HCCLM3	NA	NA	NA	NA	NA	BALB/c nude mice xenograft for HCCLM3 cell line	2.0E+8 pfu	NA	Significant reduction in tumor volume from the onset of tretament and till the end of 42 days and increase in median survival time	Intratumoral	Combined therapy increases STAT1, SOCS1 and apoptosis	Combined therapy decreases expression of MMP-2, XIAP,OPN and VEGF	NA	22569271
OV_2605	Adenovirus	Ad.enAFP-E1A-delta-E1B-IL-24	DNA	Adenoviridae	Deletion of E1A, E1B and addition of AFP and IL-24	Yes	No	Virus expressing IL-24 gene	ATCC	Human liver cancer cell line	Huh-7	NA	NA	NA	NA	NA	BALB/c nude mice xenograft for Huh7 cell line (5.0E+6 cells)	4.0E+8 pfu	NA	Complete regression in tumor after 28 days	Intratumoral	Induction of apoptosis in cancer	Upregulation of GADD34	NA	22790965
OV_2630	Adenovirus	Ad-hTERT-E1a-Apoptin	DNA	Adenoviridae	Addition of E1a and apoptin before hTERT promoter	Yes	No	No	Type culture collection of chines academy, shanghai	Human gastric cancer cell line	SGC-7901	NA	NA	NA	NA	NA	BALB/c nude mice xenograft for SGC7901 (1.0E+6 cells)	1.0E+9 pfu	NA	Complete regression in tumor after 9 weeks and increase in median survival time upto 55 days	Intratumoral	Induction of apoptosis in cancer	NA	NA	22842823
OV_2631	Adenovirus	Ad-hTERT-E1a-Apoptin	DNA	Adenoviridae	Addition of E1a and apoptin before hTERT promoter	Yes	No	No	Type culture collection of chines academy, shanghai	Human gastric cancer cell line	SGC-7901	NA	NA	NA	NA	NA	BALB/c nude mice xenograft for SGC7901 (1.0E+6 cells)	1.0E+9 pfu	NA	Significant reduction in tumor volume and increase in median survival time ipto 345 days	Intravenous	Induction of apoptosis in cancer	NA	NA	22842823
OV_2664	Adenovirus	SG500-dNK	DNA	Adenoviridae	Addition of deoxyribonucleoside kinase	No	Virus in combination with drug dFdC (1 micromolar)	No	Shanghai cell collection	Human breast cancer cell line	MDA-MB-231	NA	NA	NA	NA	NA	BALB/c nude mice xenograft for MDA-MB-231(5.0E+6 cells)	1.0E+9 pfu	NA	Increase in median survival time to more than 100 days compared to control and reduction in tumor volume 663.85 +/- 379.39mm compared to control 1336.46 +/- 614.81	NA	Combination of drug and virus increase the apoptosis process	NA	NA	23000515
OV_2755	Adenovirus	AdCN205	DNA	Adenoviridae	None	No	Virus strain in combination with miR-34-a	Virus expressing IL-24 gene	ATCC	Human hepatocellular carcinoma cell line	Huh-7	NA	NA	NA	NA	NA	BALB/c nude mice xenograft for Huh cell (2.0E+6 cell)	7.0E+8 pfu	NA	Complete regression in tumor volume after 49 days	Intratumoral	Induction of apoptosis, G1 arrest and sensescence	Inhibition of oncogene and antiapototic gene	NA	23292172
OV_2805	Adenovirus	Ad.sp-E1A-TSLC1	DNA	Adenoviridae	Deletion of 24bp with in E1A gene and insertion of TSLC1 gene	Yes	No	No	ATCC	Human lung cancer cell line	A549	NA	NA	NA	NA	NA	BALB/c nude mice xenograft for A549	5.0E+8 pfu	NA	Significant reduction in tumor volume and increased in survival rate fro 15% to 87% at day 60	Intratumoral	Induction of apotosis by virus in cancer cell line as measured by TUNEL assay	NA	NA	23503473
OV_2812	Adenovirus	G47-delta	DNA	Adenoviridae	None	No	Virus strain in combination with palcitaxel (16 nm)	No	Sun-sen university cancer centre, china	Human breast cancer cell line	MDA-MB-468	NA	NA	NA	NA	NA	BALB/c nude mice xenograft for MDA-MB-468 (5.0E+6 cells)	2.0E+5 pfu	NA	Reduction in tumor volume after 35 days	Intratumoral	Mitotic arrest and induction of apoptosis	NA	NA	23525624
OV_2866	Adenovirus	SG7605-11R-p53	DNA	Adenoviridae	Addition of p53 gene and 11R CPP	Yes	No	No	Eastern hepatobility hospital	Gallbladder cancer cell line	EH-GB2	NA	NA	NA	NA	NA	BALB/c nude mice xenograft for EH-GB2	1.0E+9 pfu	NA	Signficant reduction in tumor volume after day 30 and increase in median survival time	Intratumoral	Increase in apoptosis rate to 67% in cancer cell compared to normal	NA	NA	23727990
OV_2931	Measles virus	wild type	RNA	Paramyxoviridae	None	Yes	No	No	Laboratory grown own culture	Leukemia cell line	U937	NA	NA	NA	NA	NA	BALB/c nude mice xenograft for U937	1.0E+5 pfu	NA	Tumor volume regressed to below 12.5 mm after 14 days	Intratumoral	Induction of apoptosis by virus alone and in combination	NA	NA	25193462
OV_2932	Mumps virus	wild type	RNA	Paramyxoviridae	None	Yes	No	No	Laboratory grown own culture	Leukemia cell line	U937	NA	NA	NA	NA	NA	BALB/c nude mice xenograft for U937	1.0E+5 pfu	NA	Tumor volume regressed to below 5 mm after 14 days	Intratumoral	Induction of apoptosis by virus alone and in combination	NA	NA	25193462
OV_2933	Measles and mumps virus	wild type	RNA	Paramyxoviridae	None	No	Measles in combination with mumps	No	Laboratory grown own culture	Leukemia cell line	U937	NA	NA	NA	NA	NA	BALB/c nude mice xenograft for U937	1.0E+5 pfu	NA	Tumor volume regressed near to 2.5 mm after 14 days	Intratumoral	Induction of apoptosis by virus alone and in combination	NA	NA	25193462
OV_2934	Newcastle disease virus	wild type	RNA	Paramyxoviridae	Expressing rl gene	Yes	No	No	Peking university china	Human lung cancer cell line	A549	NA	NA	NA	NA	NA	BALB/c nude mice xenograft for A549 cell line (6.3E+8)	6.3E+8 pfu	NA	Tumor volume regressed to 274 +/- 114.20 compared to control 271.78 +/- 110.79 after day 1	Intratumoral	Induction of apoptosis by virus	NA	NA	25364430
OV_2935	Newcastle disease virus	wild type	RNA	Paramyxoviridae	Expressing rl gene	Yes	No	No	Peking university china	Human lung cancer cell line	A549	NA	NA	NA	NA	NA	BALB/c nude mice xenograft for A549 cell line (6.3E+8)	6.3E+8 pfu	NA	Tumor volume regressed to 444.18 +/- 111.22 compared to control 591.45 +/- 244.50 after day 7	Intratumoral	Induction of apoptosis by virus	NA	NA	25364430
OV_2936	Newcastle disease virus	wild type	RNA	Paramyxoviridae	Expressing rl gene	Yes	No	No	Peking university china	Human lung cancer cell line	A549	NA	NA	NA	NA	NA	BALB/c nude mice xenograft for A549 cell line (6.3E+8)	6.3E+8 pfu	NA	Tumor volume regressed to 657.56 +/- 176.74 compared to control 1483.21 +/- 446.75 after 14 day	Intratumoral	Induction of apoptosis by virus	NA	NA	25364430
OV_2937	Newcastle disease virus	wild type	RNA	Paramyxoviridae	Expressing rl gene	Yes	No	No	Peking university china	Human lung cancer cell line	A549	NA	NA	NA	NA	NA	BALB/c nude mice xenograft for A549 cell line (6.3E+8)	6.3E+8 pfu	NA	Tumor volume regressed to 804.96 +/- 176.74 compared to control 1127.88 +/- 274.09 after 21 days	Intratumoral	Induction of apoptosis by virus	NA	NA	25364430
OV_3137	Sendai virus	uPA2	RNA	Paramyxoviridae	Deletion of M, F gen at cytoplasmic location	Yes	No	No	Japan collection of research bioresources cell bank	Human anaplastic thyroid carcinoma cell line	KHM-5M	NA	NA	NA	NA	NA	BALB/c nude mice xenograft for KHM-5M cell line (2.5E+5)	1.0E+6 CIU per dose	NA	Reduction in tumor weight and increase in survival time 41.6 +/- 15 days	Intratumoral	Caspase dependent induction of apoptosis in vivo and in vitro	NA	NA	30969451
OV_3175	Semliki forest virus	SFV-VA7	RNA	Togaviridae	None	Yes	No	No	ATCC	Human prostate cancer cell line	LNCaP	NA	NA	NA	NA	NA	CAnM.Cg-Foxn1nu/Crl Balb/c nude mice subcutaneous xenograft for LNCaP (5.0E+6)	1.0E+6 pfu	NA	Complete regression in tumor volume after 20 days	Intraperitoneal	NA	NA	NA	28557974
OV_3176	Semliki forest virus	SFV-VA7	RNA	Togaviridae	None	Yes	No	No	ATCC	Human prostate cancer cell line	LNCaP	NA	NA	NA	NA	NA	CAnM.Cg-Foxn1nu/Crl Balb/c nude mice subcutaneous xenograft for LNCaP (5.0E+6)	1.0E+6 pfu	NA	Complete regression in tumor volume after 20 days	Intraperitoneal	NA	NA	NA	28557974
OV_3297	Maraba virus	MG1	RNA	Rhabdoviridae	None	Yes	No	No	ATCC	Murine sarcoma cell line	S180	NA	NA	NA	NA	NA	Balb/c nude mice isograft for S180 mouse tumor cell line (1.0E+6)	1.0E+8 pfu	NA	Complete regression in tumor volume after 97 days	Intratumoral	NA	Genration of memory immune response by incresing production of cytokines	NA	28568891
OV_3298	Newcastle disease virus	R2B mukteshwar strain	RNA	Paramyxoviridae	None	Yes	No	No	NA	Human colon cancer cell line	SW620	NA	NA	NA	NA	NA	Balb/c nude mice xenograft for SW-620 cell line (1.0E+6)	1.0E+7 pfu	NA	Tumor volume become 81.1% as compared to control 100% after day 3	Intratumoral	Induction of necrosis and apoptosis in animal model cancer cell line	NA	NA	28578522
OV_3299	Newcastle disease virus	R2B mukteshwar strain	RNA	Paramyxoviridae	None	Yes	No	No	NA	Human colon cancer cell line	SW620	NA	NA	NA	NA	NA	Balb/c nude mice xenograft for SW-620 cell line (1.0E+6)	1.0E+7 pfu	NA	Tumor volume become 89.7% as compared to control 100% after day 5	Intratumoral	Induction of necrosis and apoptosis in animal model cancer cell line	NA	NA	28578522
OV_3300	Newcastle disease virus	R2B mukteshwar strain	RNA	Paramyxoviridae	None	Yes	No	No	NA	Human colon cancer cell line	SW620	NA	NA	NA	NA	NA	Balb/c nude mice xenograft for SW-620 cell line (1.0E+6)	1.0E+7 pfu	NA	Tumor volume become 80.7% as compared to control 100% after day 8	Intratumoral	Induction of necrosis and apoptosis in animal model cancer cell line	NA	NA	28578522
OV_3301	Newcastle disease virus	R2B mukteshwar strain	RNA	Paramyxoviridae	None	Yes	No	No	NA	Human colon cancer cell line	SW620	NA	NA	NA	NA	NA	Balb/c nude mice xenograft for SW-620 cell line (1.0E+6)	1.0E+7 pfu	NA	Tumor volume become 71.9% as compared to control 100% after day 10	Intratumoral	Induction of necrosis and apoptosis in animal model cancer cell line	NA	NA	28578522
OV_3302	Newcastle disease virus	R2B mukteshwar strain	RNA	Paramyxoviridae	None	Yes	No	No	NA	Human colon cancer cell line	SW620	NA	NA	NA	NA	NA	Balb/c nude mice xenograft for SW-620 cell line (1.0E+6)	1.0E+7 pfu	NA	Tumor volume become 68.1% as compared to control 100% after day 12	Intratumoral	Induction of necrosis and apoptosis in animal model cancer cell line	NA	NA	28578522
OV_3303	Newcastle disease virus	R2B mukteshwar strain	RNA	Paramyxoviridae	None	Yes	No	No	NA	Human colon cancer cell line	SW620	NA	NA	NA	NA	NA	Balb/c nude mice xenograft for SW-620 cell line (1.0E+6)	1.0E+7 pfu	NA	Tumor volume become 58.4% as compared to control 100% after day 15	Intratumoral	Induction of necrosis and apoptosis in animal model cancer cell line	NA	NA	28578522
OV_3304	Newcastle disease virus	R2B mukteshwar strain	RNA	Paramyxoviridae	None	Yes	No	No	NA	Human colon cancer cell line	SW620	NA	NA	NA	NA	NA	Balb/c nude mice xenograft for SW-620 cell line (1.0E+6)	1.0E+7 pfu	NA	Tumor volume become 57.1% as compared to control 100% after day 17	Intratumoral	Induction of necrosis and apoptosis in animal model cancer cell line	NA	NA	28578522
OV_3305	Newcastle disease virus	R2B mukteshwar strain	RNA	Paramyxoviridae	None	Yes	No	No	NA	Human colon cancer cell line	SW620	NA	NA	NA	NA	NA	Balb/c nude mice xenograft for SW-620 cell line (1.0E+6)	1.0E+7 pfu	NA	Tumor volume become 58.3% as compared to control 100% after day 19	Intratumoral	Induction of necrosis and apoptosis in animal model cancer cell line	NA	NA	28578522
OV_3306	Newcastle disease virus	R2B mukteshwar strain	RNA	Paramyxoviridae	None	Yes	No	No	NA	Human colon cancer cell line	SW620	NA	NA	NA	NA	NA	Balb/c nude mice xenograft for SW-620 cell line (1.0E+6)	1.0E+7 pfu	NA	Tumor volume become 67.8% as compared to control 100% after day 3	Intravenous	Induction of necrosis and apoptosis in animal model cancer cell line	NA	NA	28578522
OV_3307	Newcastle disease virus	R2B mukteshwar strain	RNA	Paramyxoviridae	None	Yes	No	No	NA	Human colon cancer cell line	SW620	NA	NA	NA	NA	NA	Balb/c nude mice xenograft for SW-620 cell line (1.0E+6)	1.0E+7 pfu	NA	Tumor volume become 60.8% as compared to control 100% after day 5	Intravenous	Induction of necrosis and apoptosis in animal model cancer cell line	NA	NA	28578522
OV_3308	Newcastle disease virus	R2B mukteshwar strain	RNA	Paramyxoviridae	None	Yes	No	No	NA	Human colon cancer cell line	SW620	NA	NA	NA	NA	NA	Balb/c nude mice xenograft for SW-620 cell line (1.0E+6)	1.0E+7 pfu	NA	Tumor volume become 62.4% as compared to control 100% after day 8	Intravenous	Induction of necrosis and apoptosis in animal model cancer cell line	NA	NA	28578522
OV_3309	Newcastle disease virus	R2B mukteshwar strain	RNA	Paramyxoviridae	None	Yes	No	No	NA	Human colon cancer cell line	SW620	NA	NA	NA	NA	NA	Balb/c nude mice xenograft for SW-620 cell line (1.0E+6)	1.0E+7 pfu	NA	Tumor volume become 64.7% as compared to control 100% after day 10	Intravenous	Induction of necrosis and apoptosis in animal model cancer cell line	NA	NA	28578522
OV_3310	Newcastle disease virus	R2B mukteshwar strain	RNA	Paramyxoviridae	None	Yes	No	No	NA	Human colon cancer cell line	SW620	NA	NA	NA	NA	NA	Balb/c nude mice xenograft for SW-620 cell line (1.0E+6)	1.0E+7 pfu	NA	Tumor volume become 64.4% as compared to control 100% after day 12	Intravenous	Induction of necrosis and apoptosis in animal model cancer cell line	NA	NA	28578522
OV_3311	Newcastle disease virus	R2B mukteshwar strain	RNA	Paramyxoviridae	None	Yes	No	No	NA	Human colon cancer cell line	SW620	NA	NA	NA	NA	NA	Balb/c nude mice xenograft for SW-620 cell line (1.0E+6)	1.0E+7 pfu	NA	Tumor volume become 61.5% as compared to control 100% after day 15	Intravenous	Induction of necrosis and apoptosis in animal model cancer cell line	NA	NA	28578522
OV_3312	Newcastle disease virus	R2B mukteshwar strain	RNA	Paramyxoviridae	None	Yes	No	No	NA	Human colon cancer cell line	SW620	NA	NA	NA	NA	NA	Balb/c nude mice xenograft for SW-620 cell line (1.0E+6)	1.0E+7 pfu	NA	Tumor volume become 59.7% as compared to control 100% after day 17	Intravenous	Induction of necrosis and apoptosis in animal model cancer cell line	NA	NA	28578522
OV_3313	Newcastle disease virus	R2B mukteshwar strain	RNA	Paramyxoviridae	None	Yes	No	No	NA	Human colon cancer cell line	SW620	NA	NA	NA	NA	NA	Balb/c nude mice xenograft for SW-620 cell line (1.0E+6)	1.0E+7 pfu	NA	Tumor volume become 59.9% as compared to control 100% after day 19	Intravenous	Induction of necrosis and apoptosis in animal model cancer cell line	NA	NA	28578522
OV_3498	Adenovirus	Adenovirus CRAds	DNA	Adenoviridae	None	Yes	No	No	Cell collection centre china	Human lung cancer cell line	A549	NA	NA	NA	NA	NA	Balb/c nude mice xenograft for SW-620 cell line (1.0E+6)	8.0E+6 pfu	NA	Tumor size regressed to 700mm compared to control 900mm after 65 days	Intratumoral	NA	NA	NA	28638457
OV_3499	Adenovirus	Adenovirus CRAds	DNA	Adenoviridae	None	No	Virus in combination with cisplatin	No	Cell collection centre china	Human lung cancer cell line	A549	NA	NA	NA	NA	NA	Balb/c nude mice xenograft for SW-620 cell line (1.0E+6)	8.0E+6 pfu	NA	Tumor size regressed to 100mm compared to control 900mm after 65 days	Intratumoral	NA	NA	NA	28638457
OV_3500	Adenovirus	Adenovirus CRAds	DNA	Adenoviridae	None	Yes	No	No	Cell collection centre china	Human lung cancer cell line	A549-DDPR cisplatin resistant	NA	NA	NA	NA	NA	Balb/c nude mice xenograft for SW-620 cell line (1.0E+6)	8.0E+6 pfu	NA	Tumor size regressed to 800mm compared to control 900mm after 65 days	Intratumoral	NA	NA	NA	28638457
OV_3501	Adenovirus	Adenovirus CRAds	DNA	Adenoviridae	None	No	Virus in combination with cisplatin	No	Cell collection centre china	Human lung cancer cell line	A549-DDPR cisplatin resistant	NA	NA	NA	NA	NA	Balb/c nude mice xenograft for SW-620 cell line (1.0E+6)	8.0E+6 pfu	NA	Tumor size regressed to 300mm compared to control 900mm after 65 days	Intratumoral	NA	NA	NA	28638457
OV_3520	Adenovirus	Adenovirus ZD55-shMYCN	DNA	Adenoviridae	Virus expressing MYCN gene	Yes	No	No	Lab own synthesized	Human neuroblastoma cell line	LA1-55n/Dox-R	NA	NA	NA	NA	NA	Balb/c nude mice xenograft for LA1-55n/Dox-R cell line (2.0E+6)	7.0E+8 pfu	NA	Tumor volume regressed to 800mm after four week compared to normal 1400 mm.	NA	Induction of apoptosis as measured by TUNEL assay	NA	NA	28711493
OV_3521	Adenovirus	Adenovirus ZD55-shMYCN	DNA	Adenoviridae	Virus expressing MYCN gene	No	Virus in combination with Doxorubicin	No	Lab own synthesized	Human neuroblastoma cell line	LA1-55n/Dox-R	NA	NA	NA	NA	NA	Balb/c nude mice xenograft for LA1-55n/Dox-R cell line (2.0E+6)	7.0E+8 pfu	NA	Tumor volume regressed to 300mm after four week compared to normal 1400 mm.	NA	Induction of apoptosis as measured by TUNEL assay	NA	NA	28711493
OV_3618	Adenovirus	Adenovirus CD55-TRAIL	DNA	Adenoviridae	Virus expressingTRAIL gene	No	Virus in combination with luteolin (50mg/kg)	No	Shanghai cell collection	Human colorectal cancer cell line	HT-29	NA	NA	NA	NA	NA	Balb/c nude mice xenograft for HT29 cell line (8.0E+6)	2.0E+9 pfu	NA	Decrease in tumor volume to below 2000mm after 30 days comapred to control 4000mm	Intratumoral	Virus in combination with induce apiptosis in cancer cell	NA	NA	29039580
OV_3737	Vesicular stomatitis virus	VSV-GP	RNA	Rhabdoviridae	virus expressing GP protein	Yes	No	No	ATCC	Human prostate cancer cell line	Du145	NA	NA	NA	NA	NA	Balb/c-rag and gamma negative xenograft for Du145 (2.0E+6)	1.0E+7 pfu	NA	Complete regression in tumor after day 80	Intratumoral	NA	NA	NA	29696636