Detailed description page of Selected OV_ID


OV_2553 details
Primary information
OV_IDOV_2553
Virus Name Adenovirus
StrainAD55-Apoptin
Virus typeDNA
Virus familyAdenoviridae
Modification in virus genomeDeletion of E1B gene and insertion of Apoptin gene
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeNo
Source of cell lineATCC
Origin of cell lineHuman hepatocellular carcinoma cell line
Cell lineHuh-7
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismBALB/c nude mice xenograft for Huh7 cell line (1 × 10⁷)
In-vivo virus concentration3 × 10⁸ pfu
In-vivo toxicityNA
In-vivo resultReduction in tumor volume below 425mm after 16 days
Mode of deliveryIntratumoral
Pathway inductionInduction of apotosis as measured by TUNEL assay
Immunogenic effectNA
Clinical trialNA
PMID22321574