Detailed description page of Selected OV_ID


OV_401 details
Primary information
OV_IDOV_401
Virus Name Herpes simplex virus
StrainICP10PK
Virus typeDNA
Virus familyHerpesviridae
Modification in virus genomeDeletion mutant with R1 domain poorly functional in HSV-1
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeNo
Source of cell lineNA
Origin of cell lineNA
Cell lineNA
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismXenograft male BALB/c nu/nu mice (subcutaneously injected with 10⁷ A3755 cells in 100 μl)
In-vivo virus concentration100 μl; 10⁶ PFU on day 7
In-vivo toxicityNA
In-vivo resultOn day 29 , tumor growth ratio reached 2 as compared to 13 (tumour growth ratio - dividing each tumour volume measured over time by the initial tumour volume on day 7)
Mode of deliveryIntratumorally
Pathway inductionNA
Immunogenic effectMICA and TNF-alpha expressions are upregulated
Clinical trialNA
PMID26602205