| Primary information |
|---|
| OV_ID | OV_2936 |
| Virus Name | Newcastle disease virus |
| Strain | wild type |
| Virus type | RNA |
| Virus family | Paramyxoviridae |
| Modification in virus genome | Expressing rl gene |
| Virus alone | Yes |
| Virus in combination iwth drug/radiation | No |
| Immune gene induction in virus genome | No |
| Source of cell line | Peking university china |
| Origin of cell line | Human lung cancer cell line |
| Cell line | A549 |
| Concentration of cell line | 0 |
| In-vitro toxicity | NA |
| Assay | NA |
| In-vitro virus concentration | NA |
| In-vitro result | NA |
| Model organism | BALB/c nude mice xenograft for A549 cell line (6.3 × 10â¸) |
| In-vivo virus concentration | 6.3 × 10⸠pfu |
| In-vivo toxicity | NA |
| In-vivo result | Tumor volume regressed to 657.56 +/- 176.74 compared to control 1483.21 +/- 446.75 after 14 day |
| Mode of delivery | Intratumoral |
| Pathway induction | Induction of apoptosis by virus |
| Immunogenic effect | NA |
| Clinical trial | NA |
| PMID | 25364430 |