Detailed description page of Selected OV_ID


OV_358 details
Primary information
OV_IDOV_358
Virus Name Adenovirus
StrainAdhz60
Virus typeDNA
Virus familyAdenoviridae
Modification in virus genomeE1b-deleted mutant
Virus aloneNo
Virus in combination iwth drug/radiationVirus in combination with temozolomide (TMZ) intraperitoneally at 50 mg/Kg for five consecutive days
Immune gene induction in virus genomeNo
Source of cell lineNA
Origin of cell lineNA
Cell lineNA
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismAthymic BALB/c nu/nu male mice (subcutaneously injected A549 lung cancer cells, 5 × 10⁶ cells )
In-vivo virus concentration1 × 10⁹ pfu (every 3 days for at total 4 treatments)
In-vivo toxicityNA
In-vivo result70% smaller tumor size compared to the negative control virus AdLacZ
Mode of deliveryIntratumorally
Pathway inductionJNK activation induces autophagy
Immunogenic effectNA
Clinical trialNA
PMID26561948