Detailed description page of Selected OV_ID


OV_603 details
Primary information
OV_IDOV_603
Virus Name Alphavirus
StrainM1
Virus typeRNA
Virus familyTogaviridae
Modification in virus genomeNone
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeNo
Source of cell lineNA
Origin of cell lineNA
Cell lineNA
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismFemale BALB/c-nu/nu mice inoculated subcutaneously with HCT-116, 5x10⁶ cells/mouse
In-vivo virus concentration3×10⁷ PFU/d
In-vivo toxicityNA
In-vivo resultReduction in tumor volume to 0.76 cubic centimeter compared to control 1cubic centimeter after 27 days
Mode of deliveryintravenously
Pathway inductionActivates Caspase-3 (very small)
Immunogenic effectNA
Clinical trialNA
PMID27374176