| Primary information |
|---|
| OV_ID | OV_1136 |
| Virus Name | Sindbis virus |
| Strain | AR339 |
| Virus type | RNA |
| Virus family | Togaviridae |
| Modification in virus genome | None |
| Virus alone | Yes |
| Virus in combination iwth drug/radiation | No |
| Immune gene induction in virus genome | No |
| Source of cell line | NA |
| Origin of cell line | NA |
| Cell line | NA |
| Concentration of cell line | 0 |
| In-vitro toxicity | NA |
| Assay | NA |
| In-vitro virus concentration | NA |
| In-vitro result | NA |
| Model organism | BALB/c nude mice xenograft for HeLaS3 cell line |
| In-vivo virus concentration | 1 × 10ⶠpfu
|
| In-vivo toxicity | NA |
| In-vivo result | Complete reduction in tumor volume after 30 days |
| Mode of delivery | Intratumoral injection |
| Pathway induction | Apoptosis induction in cancer cell lines |
| Immunogenic effect | NA |
| Clinical trial | |
| PMID | 15958641 |