| Primary information |
|---|
| OV_ID | OV_3618 |
| Virus Name | Adenovirus |
| Strain | Adenovirus CD55-TRAIL |
| Virus type | DNA |
| Virus family | Adenoviridae |
| Modification in virus genome | Virus expressingTRAIL gene |
| Virus alone | No |
| Virus in combination iwth drug/radiation | Virus in combination with luteolin (50mg/kg) |
| Immune gene induction in virus genome | No |
| Source of cell line | Shanghai cell collection |
| Origin of cell line | Human colorectal cancer cell line |
| Cell line | HT-29 |
| Concentration of cell line | 0 |
| In-vitro toxicity | NA |
| Assay | NA |
| In-vitro virus concentration | NA |
| In-vitro result | NA |
| Model organism | Balb/c nude mice xenograft for HT29 cell line (8 × 10â¶) |
| In-vivo virus concentration | 2 × 10⹠pfu
|
| In-vivo toxicity | NA |
| In-vivo result | Decrease in tumor volume to below 2000mm after 30 days comapred to control 4000mm |
| Mode of delivery | Intratumoral |
| Pathway induction | Virus in combination with induce apiptosis in cancer cell |
| Immunogenic effect | NA |
| Clinical trial | NA |
| PMID | 29039580 |