Detailed description page of Selected OV_ID


OV_3618 details
Primary information
OV_IDOV_3618
Virus Name Adenovirus
StrainAdenovirus CD55-TRAIL
Virus typeDNA
Virus familyAdenoviridae
Modification in virus genomeVirus expressingTRAIL gene
Virus aloneNo
Virus in combination iwth drug/radiationVirus in combination with luteolin (50mg/kg)
Immune gene induction in virus genomeNo
Source of cell lineShanghai cell collection
Origin of cell lineHuman colorectal cancer cell line
Cell lineHT-29
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismBalb/c nude mice xenograft for HT29 cell line (8 × 10⁶)
In-vivo virus concentration2 × 10⁹ pfu
In-vivo toxicityNA
In-vivo resultDecrease in tumor volume to below 2000mm after 30 days comapred to control 4000mm
Mode of deliveryIntratumoral
Pathway inductionVirus in combination with induce apiptosis in cancer cell
Immunogenic effectNA
Clinical trialNA
PMID29039580