Detailed description page of Selected OV_ID


OV_2605 details
Primary information
OV_IDOV_2605
Virus Name Adenovirus
StrainAd.enAFP-E1A-delta-E1B-IL-24
Virus typeDNA
Virus familyAdenoviridae
Modification in virus genomeDeletion of E1A, E1B and addition of AFP and IL-24
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeVirus expressing IL-24 gene
Source of cell lineATCC
Origin of cell lineHuman liver cancer cell line
Cell lineHuh-7
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismBALB/c nude mice xenograft for Huh7 cell line (5 × 10⁶ cells)
In-vivo virus concentration4 × 10⁸ pfu
In-vivo toxicityNA
In-vivo resultComplete regression in tumor after 28 days
Mode of deliveryIntratumoral
Pathway inductionInduction of apoptosis in cancer
Immunogenic effectUpregulation of GADD34
Clinical trialNA
PMID22790965