| Primary information |
|---|
| OV_ID | OV_2605 |
| Virus Name | Adenovirus |
| Strain | Ad.enAFP-E1A-delta-E1B-IL-24 |
| Virus type | DNA |
| Virus family | Adenoviridae |
| Modification in virus genome | Deletion of E1A, E1B and addition of AFP and IL-24 |
| Virus alone | Yes |
| Virus in combination iwth drug/radiation | No |
| Immune gene induction in virus genome | Virus expressing IL-24 gene |
| Source of cell line | ATCC |
| Origin of cell line | Human liver cancer cell line |
| Cell line | Huh-7 |
| Concentration of cell line | 0 |
| In-vitro toxicity | NA |
| Assay | NA |
| In-vitro virus concentration | NA |
| In-vitro result | NA |
| Model organism | BALB/c nude mice xenograft for Huh7 cell line (5 × 10ⶠcells) |
| In-vivo virus concentration | 4 × 10⸠pfu
|
| In-vivo toxicity | NA |
| In-vivo result | Complete regression in tumor after 28 days |
| Mode of delivery | Intratumoral |
| Pathway induction | Induction of apoptosis in cancer |
| Immunogenic effect | Upregulation of GADD34 |
| Clinical trial | NA |
| PMID | 22790965 |