| Primary information |
|---|
| OV_ID | OV_1353 |
| Virus Name | Adenovirus |
| Strain | AdCN103 |
| Virus type | DNA |
| Virus family | Adenoviridae |
| Modification in virus genome | 24 bp deletion in hTERT promoter |
| Virus alone | Yes |
| Virus in combination iwth drug/radiation | No |
| Immune gene induction in virus genome | No |
| Source of cell line | NA |
| Origin of cell line | NA |
| Cell line | NA |
| Concentration of cell line | 0 |
| In-vitro toxicity | NA |
| Assay | NA |
| In-vitro virus concentration | NA |
| In-vitro result | NA |
| Model organism | BALB/c nude mice, xenograft for BEL7404 |
| In-vivo virus concentration | 2 × 10⸠pfu
|
| In-vivo toxicity | NA |
| In-vivo result | Significant reduction in tumor volume after 7 weeks and increase in survival |
| Mode of delivery | Intratumoral |
| Pathway induction | NA |
| Immunogenic effect | NA |
| Clinical trial | NA |
| PMID | 18281783 |