Detailed description page of Selected OV_ID


OV_1353 details
Primary information
OV_IDOV_1353
Virus Name Adenovirus
StrainAdCN103
Virus typeDNA
Virus familyAdenoviridae
Modification in virus genome24 bp deletion in hTERT promoter
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeNo
Source of cell lineNA
Origin of cell lineNA
Cell lineNA
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismBALB/c nude mice, xenograft for BEL7404
In-vivo virus concentration2 × 10⁸ pfu
In-vivo toxicityNA
In-vivo resultSignificant reduction in tumor volume after 7 weeks and increase in survival
Mode of deliveryIntratumoral
Pathway inductionNA
Immunogenic effectNA
Clinical trialNA
PMID18281783