| Primary information |
|---|
| OV_ID | OV_567 |
| Virus Name | Adenovirus |
| Strain | OBP-301 (telomelysin) |
| Virus type | DNA |
| Virus family | Adenoviridae |
| Modification in virus genome | Viral mutant with human telomerase reverse transcriptase (hTERT) promotor for selective replication in cancer cells |
| Virus alone | No |
| Virus in combination iwth drug/radiation | Viral strain in combination with cisplatin (CDDP, 4 mg/kg body weight ) and doxorubicin (DOX, 2 mg/kg body weight )[drugs were given intraperitoneally] |
| Immune gene induction in virus genome | No |
| Source of cell line | NA |
| Origin of cell line | NA |
| Cell line | NA |
| Concentration of cell line | 0 |
| In-vitro toxicity | NA |
| Assay | NA |
| In-vitro virus concentration | NA |
| In-vitro result | NA |
| Model organism | Xenograft female BALB/c nu/nu mice inoculated subcutaneously with MNNG/HOS-Luc cells (5 × 10ⶠcells/site) |
| In-vivo virus concentration | 5 × 10ⷠPFU |
| In-vivo toxicity | NA |
| In-vivo result | Proliferating tumor cells expressing ki67 get reduced from 550 cells to 75 cells |
| Mode of delivery | Direct injection |
| Pathway induction | NA |
| Immunogenic effect | NA |
| Clinical trial | NA |
| PMID | 27356624 |