| Primary information |
|---|
| OV_ID | OV_3521 |
| Virus Name | Adenovirus |
| Strain | Adenovirus ZD55-shMYCN |
| Virus type | DNA |
| Virus family | Adenoviridae |
| Modification in virus genome | Virus expressing MYCN gene |
| Virus alone | No |
| Virus in combination iwth drug/radiation | Virus in combination with Doxorubicin |
| Immune gene induction in virus genome | No |
| Source of cell line | Lab own synthesized |
| Origin of cell line | Human neuroblastoma cell line |
| Cell line | LA1-55n/Dox-R |
| Concentration of cell line | 0 |
| In-vitro toxicity | NA |
| Assay | NA |
| In-vitro virus concentration | NA |
| In-vitro result | NA |
| Model organism | Balb/c nude mice xenograft for LA1-55n/Dox-R cell line (2 × 10â¶) |
| In-vivo virus concentration | 7 × 10⸠pfu
|
| In-vivo toxicity | NA |
| In-vivo result | Tumor volume regressed to 300mm after four week compared to normal 1400 mm. |
| Mode of delivery | NA |
| Pathway induction | Induction of apoptosis as measured by TUNEL assay |
| Immunogenic effect | NA |
| Clinical trial | NA |
| PMID | 28711493 |