Detailed description page of Selected OV_ID


OV_3521 details
Primary information
OV_IDOV_3521
Virus Name Adenovirus
StrainAdenovirus ZD55-shMYCN
Virus typeDNA
Virus familyAdenoviridae
Modification in virus genomeVirus expressing MYCN gene
Virus aloneNo
Virus in combination iwth drug/radiationVirus in combination with Doxorubicin
Immune gene induction in virus genomeNo
Source of cell lineLab own synthesized
Origin of cell lineHuman neuroblastoma cell line
Cell lineLA1-55n/Dox-R
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismBalb/c nude mice xenograft for LA1-55n/Dox-R cell line (2 × 10⁶)
In-vivo virus concentration7 × 10⁸ pfu
In-vivo toxicityNA
In-vivo resultTumor volume regressed to 300mm after four week compared to normal 1400 mm.
Mode of deliveryNA
Pathway inductionInduction of apoptosis as measured by TUNEL assay
Immunogenic effectNA
Clinical trialNA
PMID28711493