Detailed description page of Selected OV_ID


OV_752 details
Primary information
OV_IDOV_752
Virus Name Adenovirus
StrainAdAFPp-E1A-122
Virus typeDNA
Virus familyAdenoviridae
Modification in virus genomeThe viral insertion mutant with miR-122 target sequence into AdAFPp-E1A for negatively regulating E1A gene expression
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeNo
Source of cell lineNA
Origin of cell lineNA
Cell lineNA
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismHepG2 subcutaneous liver xenograft tumor in Balb/c athymic nude
In-vivo virus concentrationNA
In-vivo toxicityNA
In-vivo resultReduction in tumor volume to 0.8 cubic centimeter compared to control 2.4 cubic centimeter after 15 days
Mode of deliveryintravenously
Pathway inductionNA
Immunogenic effectNA
Clinical trialNA
PMID27450327