Detailed description page of Selected OV_ID


OV_1104 details
Primary information
OV_IDOV_1104
Virus Name Adenovirus
StrainAd-IL-24
Virus typeDNA
Virus familyAdenoviridae
Modification in virus genomeAdenovirus expressing IL-24 gene
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeExpressing IL-24 gene
Source of cell lineShanghai cell collection
Origin of cell lineNA
Cell lineNA
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismAthymic BALB/c nude mice xenograft for SW620 cell line
In-vivo virus concentration5 × 10⁸ cells per well
In-vivo toxicityNA
In-vivo resultDecrease in tumor volume below 600mm³ as compared to control
Mode of deliveryIntratumoral injection
Pathway inductionApoptosis induction and cspase 3 activation
Immunogenic effectNA
Clinical trialNA
PMID15661558