Detailed description page of Selected OV_ID


OV_2138 details
Primary information
OV_IDOV_2138
Virus Name Adenovirus
StrainMutant
Virus typeDNA
Virus familyAdenoviridae
Modification in virus genomeDeletion of E1BK55KD gene and addition of TRAIL gene
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeVirus expressing TRAIL gene
Source of cell lineATCC
Origin of cell lineHuman hepatocellular carcinoma cell line
Cell lineHuh-7
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismBALB/c mice xenograft for Huh7 cell line (5 × 10⁶ pfu)
In-vivo virus concentration2× 10⁹ pfu
In-vivo toxicityNA
In-vivo resultSignificant reduction in tumor volume below 100mm and increase in median survival time after 57 days
Mode of deliveryIntratumoral
Pathway inductionInduction of apoptosis in cancer as measured by TUNEL assay
Immunogenic effectNA
Clinical trialNA
PMID21979578