| Primary information |
|---|
| OV_ID | OV_2138 |
| Virus Name | Adenovirus |
| Strain | Mutant |
| Virus type | DNA |
| Virus family | Adenoviridae |
| Modification in virus genome | Deletion of E1BK55KD gene and addition of TRAIL gene |
| Virus alone | Yes |
| Virus in combination iwth drug/radiation | No |
| Immune gene induction in virus genome | Virus expressing TRAIL gene |
| Source of cell line | ATCC |
| Origin of cell line | Human hepatocellular carcinoma cell line |
| Cell line | Huh-7 |
| Concentration of cell line | 0 |
| In-vitro toxicity | NA |
| Assay | NA |
| In-vitro virus concentration | NA |
| In-vitro result | NA |
| Model organism | BALB/c mice xenograft for Huh7 cell line (5 × 10ⶠpfu) |
| In-vivo virus concentration | 2× 10⹠pfu
|
| In-vivo toxicity | NA |
| In-vivo result | Significant reduction in tumor volume below 100mm and increase in median survival time after 57 days |
| Mode of delivery | Intratumoral |
| Pathway induction | Induction of apoptosis in cancer as measured by TUNEL assay |
| Immunogenic effect | NA |
| Clinical trial | NA |
| PMID | 21979578 |