| Primary information |
|---|
| OV_ID | OV_39 |
| Virus Name | Adenovirus |
| Strain | oAd/DCN/LRP-PEG-NT |
| Virus type | DNA |
| Virus family | Adenoviridae |
| Modification in virus genome | Insertional mutant for DCN and LRP gene with NT-conjugated polyethylene glycol |
| Virus alone | Yes |
| Virus in combination iwth drug/radiation | No |
| Immune gene induction in virus genome | No |
| Source of cell line | NA |
| Origin of cell line | NA |
| Cell line | NA |
| Concentration of cell line | 0 |
| In-vitro toxicity | NA |
| Assay | NA |
| In-vitro virus concentration | NA |
| In-vitro result | NA |
| Model organism | BALB/c nude mice xenograft for MIA PaCa-2 cell line (5 × 10ⶠcells) |
| In-vivo virus concentration | 2 × 10¹ⰠVP (on 0, 2, and 4 days) |
| In-vivo toxicity | NA |
| In-vivo result | Reduction in tumor volume to 100 cubic millimeter compared to control 300 cubic millimeter after 46 days |
| Mode of delivery | Intravenously |
| Pathway induction | Inhibits Wnt/β-catenin and TGF-β1 signaling pathways |
| Immunogenic effect | NA |
| Clinical trial | NA |
| PMID | 26471393 |