Detailed description page of Selected OV_ID


OV_749 details
Primary information
OV_IDOV_749
Virus Name Adenovirus
StrainAdAFPp-E1A
Virus typeDNA
Virus familyAdenoviridae
Modification in virus genomeThe viral mutant with E1A gene driven by AFP promoter
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeNo
Source of cell lineNA
Origin of cell lineNA
Cell lineNA
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismHepG2 orthotopic liver xenograft tumor in Balb/c athymic nude
In-vivo virus concentrationNA
In-vivo toxicityNA
In-vivo resultReduction in tumor weight to 0.2 g compared to control 0.75 g after 18 days
Mode of deliveryintravenously
Pathway inductionNA
Immunogenic effectNA
Clinical trialNA
PMID27450327