Detailed description page of Selected OV_ID


OV_2935 details
Primary information
OV_IDOV_2935
Virus Name Newcastle disease virus
Strainwild type
Virus typeRNA
Virus familyParamyxoviridae
Modification in virus genomeExpressing rl gene
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeNo
Source of cell linePeking university china
Origin of cell lineHuman lung cancer cell line
Cell lineA549
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismBALB/c nude mice xenograft for A549 cell line (6.3 × 10⁸)
In-vivo virus concentration6.3 × 10⁸ pfu
In-vivo toxicityNA
In-vivo resultTumor volume regressed to 444.18 +/- 111.22 compared to control 591.45 +/- 244.50 after day 7
Mode of deliveryIntratumoral
Pathway inductionInduction of apoptosis by virus
Immunogenic effectNA
Clinical trialNA
PMID25364430