| Primary information |
|---|
| OV_ID | OV_2210 |
| Virus Name | Herpes simplex virus |
| Strain | HSV-1-G47-delta |
| Virus type | DNA |
| Virus family | Herpesviridae |
| Modification in virus genome | Mutant for Gamma34.5, ICP6 and alpha47 gene |
| Virus alone | Yes |
| Virus in combination iwth drug/radiation | No |
| Immune gene induction in virus genome | No |
| Source of cell line | Hongkong university |
| Origin of cell line | Human nasopharyngeal carcinoma cell line |
| Cell line | SUNE-1 |
| Concentration of cell line | 0 |
| In-vitro toxicity | NA |
| Assay | NA |
| In-vitro virus concentration | NA |
| In-vitro result | NA |
| Model organism | Balb/c nude mice xenograft for SUNE-1 cell line (5 × 10ⵠcells) |
| In-vivo virus concentration | 2 × 10ⷠpfu
|
| In-vivo toxicity | NA |
| In-vivo result | Virus treated mice shows complete regression in tumor and exhibit longer survival time |
| Mode of delivery | Intratumoral |
| Pathway induction | NA |
| Immunogenic effect | NA |
| Clinical trial | NA |
| PMID | 22059912 |