Detailed description page of Selected OV_ID


OV_37 details
Primary information
OV_IDOV_37
Virus Name Adenovirus
StrainoAd/DCN/LRP
Virus typeDNA
Virus familyAdenoviridae
Modification in virus genomeInsertional mutant for DCN and LRP gene
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeNo
Source of cell lineNA
Origin of cell lineNA
Cell lineNA
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismBALB/c nude mice xenograft for MIA PaCa-2 cell line (5 × 10⁶ cells)
In-vivo virus concentration2 × 10¹⁰ VP (on 0, 2, and 4 days)
In-vivo toxicitySlight hepatotoxicity
In-vivo resultReduction in tumor volume to 230 cubic millimeter compared to control 300 cubic millimeter after 46 days
Mode of deliveryIntravenously
Pathway inductionInhibits Wnt/β-catenin and TGF-β1 signaling pathways
Immunogenic effectIL-6 production increased by 3 folds as compared to normal
Clinical trialNA
PMID26471393