Detailed description page of Selected OV_ID


OV_2578 details
Primary information
OV_IDOV_2578
Virus Name Adenovirus
StrainSG600-IL-24+IFN
Virus typeDNA
Virus familyAdenoviridae
Modification in virus genomeDeletion of E1B gene and insertion of IL-24 gene and addition of IN
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeVirus expressing IL-24 gene and IFN gene
Source of cell lineATCC
Origin of cell lineHuman hepatocellular carcinoma cell line
Cell lineHCCLM3
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismBALB/c nude mice xenograft for HCCLM3 cell line
In-vivo virus concentration2 × 10⁸ pfu
In-vivo toxicityNA
In-vivo resultSignificant reduction in tumor volume from the onset of tretament and till the end of 42 days and increase in median survival time
Mode of deliveryIntratumoral
Pathway inductionCombined therapy increases STAT1, SOCS1 and apoptosis
Immunogenic effectCombined therapy decreases expression of MMP-2, XIAP,OPN and VEGF
Clinical trialNA
PMID22569271