Detailed description page of Selected OV_ID


OV_2631 details
Primary information
OV_IDOV_2631
Virus Name Adenovirus
StrainAd-hTERT-E1a-Apoptin
Virus typeDNA
Virus familyAdenoviridae
Modification in virus genomeAddition of E1a and apoptin before hTERT promoter
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeNo
Source of cell lineType culture collection of chines academy, shanghai
Origin of cell lineHuman gastric cancer cell line
Cell lineSGC-7901
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismBALB/c nude mice xenograft for SGC7901 (1 × 10⁶ cells)
In-vivo virus concentration1 × 10⁹ pfu
In-vivo toxicityNA
In-vivo resultSignificant reduction in tumor volume and increase in median survival time ipto 345 days
Mode of deliveryIntravenous
Pathway inductionInduction of apoptosis in cancer
Immunogenic effectNA
Clinical trialNA
PMID22842823