| Primary information |
|---|
| OV_ID | OV_2630 |
| Virus Name | Adenovirus |
| Strain | Ad-hTERT-E1a-Apoptin |
| Virus type | DNA |
| Virus family | Adenoviridae |
| Modification in virus genome | Addition of E1a and apoptin before hTERT promoter |
| Virus alone | Yes |
| Virus in combination iwth drug/radiation | No |
| Immune gene induction in virus genome | No |
| Source of cell line | Type culture collection of chines academy, shanghai |
| Origin of cell line | Human gastric cancer cell line |
| Cell line | SGC-7901 |
| Concentration of cell line | 0 |
| In-vitro toxicity | NA |
| Assay | NA |
| In-vitro virus concentration | NA |
| In-vitro result | NA |
| Model organism | BALB/c nude mice xenograft for SGC7901 (1 × 10ⶠcells) |
| In-vivo virus concentration | 1 × 10⹠pfu
|
| In-vivo toxicity | NA |
| In-vivo result | Complete regression in tumor after 9 weeks and increase in median survival time upto 55 days |
| Mode of delivery | Intratumoral |
| Pathway induction | Induction of apoptosis in cancer |
| Immunogenic effect | NA |
| Clinical trial | NA |
| PMID | 22842823 |