| Primary information |
|---|
| OV_ID | OV_2664 |
| Virus Name | Adenovirus |
| Strain | SG500-dNK |
| Virus type | DNA |
| Virus family | Adenoviridae |
| Modification in virus genome | Addition of deoxyribonucleoside kinase |
| Virus alone | No |
| Virus in combination iwth drug/radiation | Virus in combination with drug dFdC (1 micromolar) |
| Immune gene induction in virus genome | No |
| Source of cell line | Shanghai cell collection |
| Origin of cell line | Human breast cancer cell line |
| Cell line | MDA-MB-231 |
| Concentration of cell line | 0 |
| In-vitro toxicity | NA |
| Assay | NA |
| In-vitro virus concentration | NA |
| In-vitro result | NA |
| Model organism | BALB/c nude mice xenograft for MDA-MB-231(5 × 10ⶠcells) |
| In-vivo virus concentration | 1 × 10⹠pfu
|
| In-vivo toxicity | NA |
| In-vivo result | Increase in median survival time to more than 100 days compared to control and reduction in tumor volume 663.85 +/- 379.39mm compared to control 1336.46 +/- 614.81 |
| Mode of delivery | NA |
| Pathway induction | Combination of drug and virus increase the apoptosis process |
| Immunogenic effect | NA |
| Clinical trial | NA |
| PMID | 23000515 |