Detailed description page of Selected OV_ID


OV_831 details
Primary information
OV_IDOV_831
Virus Name Adenovirus
StrainSG611
Virus typeDNA
Virus familyAdenoviridae
Modification in virus genomeNone
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeNo
Source of cell lineNA
Origin of cell lineNA
Cell lineNA
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismXenograft BALB/c nu/nu female mice subcutaneously injected with 1 × 10⁷ K562 cells in a total volume of 100 μl
In-vivo virus concentration1 × 10⁹ pfu/ml
In-vivo toxicityNA
In-vivo resultReduction in tumor volume to 120 cubic millimeter compared to control 880 cubic millimeter after 30 days
Mode of deliveryIntratumoral
Pathway inductionEnhanced apoptosis activation is observed
Immunogenic effectNA
Clinical trialNA
PMID27472927