| Primary information |
|---|
| OV_ID | OV_750 |
| Virus Name | Adenovirus |
| Strain | AdAFPp-E1A-122 |
| Virus type | DNA |
| Virus family | Adenoviridae |
| Modification in virus genome | The viral insertion mutant with miR-122 target sequence into AdAFPp-E1A for negatively regulating E1A gene expression |
| Virus alone | Yes |
| Virus in combination iwth drug/radiation | No |
| Immune gene induction in virus genome | No |
| Source of cell line | NA |
| Origin of cell line | NA |
| Cell line | NA |
| Concentration of cell line | 0 |
| In-vitro toxicity | NA |
| Assay | NA |
| In-vitro virus concentration | NA |
| In-vitro result | NA |
| Model organism | HepG2 orthotopic liver xenograft tumor in Balb/c athymic nude |
| In-vivo virus concentration | NA |
| In-vivo toxicity | NA |
| In-vivo result | Reduction in tumor weight to 0.2 g compared to control 0.75 g after 18 days |
| Mode of delivery | intravenously |
| Pathway induction | NA |
| Immunogenic effect | NA |
| Clinical trial | NA |
| PMID | 27450327 |