| Primary information |
|---|
| OV_ID | OV_2866 |
| Virus Name | Adenovirus |
| Strain | SG7605-11R-p53 |
| Virus type | DNA |
| Virus family | Adenoviridae |
| Modification in virus genome | Addition of p53 gene and 11R CPP |
| Virus alone | Yes |
| Virus in combination iwth drug/radiation | No |
| Immune gene induction in virus genome | No |
| Source of cell line | Eastern hepatobility hospital |
| Origin of cell line | Gallbladder cancer cell line |
| Cell line | EH-GB2 |
| Concentration of cell line | 0 |
| In-vitro toxicity | NA |
| Assay | NA |
| In-vitro virus concentration | NA |
| In-vitro result | NA |
| Model organism | BALB/c nude mice xenograft for EH-GB2 |
| In-vivo virus concentration | 1 × 10⹠pfu
|
| In-vivo toxicity | NA |
| In-vivo result | Signficant reduction in tumor volume after day 30 and increase in median survival time |
| Mode of delivery | Intratumoral |
| Pathway induction | Increase in apoptosis rate to 67% in cancer cell compared to normal |
| Immunogenic effect | NA |
| Clinical trial | NA |
| PMID | 23727990 |