| Primary information |
|---|
| OV_ID | OV_3500 |
| Virus Name | Adenovirus |
| Strain | Adenovirus CRAds |
| Virus type | DNA |
| Virus family | Adenoviridae |
| Modification in virus genome | None |
| Virus alone | Yes |
| Virus in combination iwth drug/radiation | No |
| Immune gene induction in virus genome | No |
| Source of cell line | Cell collection centre china |
| Origin of cell line | Human lung cancer cell line |
| Cell line | A549-DDPR cisplatin resistant |
| Concentration of cell line | 0 |
| In-vitro toxicity | NA |
| Assay | NA |
| In-vitro virus concentration | NA |
| In-vitro result | NA |
| Model organism | Balb/c nude mice xenograft for SW-620 cell line (1 × 10â¶) |
| In-vivo virus concentration | 8 × 10ⶠpfu
|
| In-vivo toxicity | NA |
| In-vivo result | Tumor size regressed to 800mm compared to control 900mm after 65 days |
| Mode of delivery | Intratumoral |
| Pathway induction | NA |
| Immunogenic effect | NA |
| Clinical trial | NA |
| PMID | 28638457 |